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Volume 10
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10.3390/children10121879
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Review

An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents

by
Dana-Teodora Anton-Păduraru
1,2,
Alina Mariela Murgu
1,2,
Mădălina Andreea Donos
1,2,*,
Felicia Trofin
3,4,
Alice Nicoleta Azoicăi
1,2,
Paula Popovici
1,2,
Aurelian Bogdan Stana
1,2,
Ionela Gheorghiescu
5 and
Laura Mihaela Trandafir
1,2
1
Department of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2
“Sf. Maria” Children Emergency Hospital, 700309 Iasi, Romania
3
Department of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
4
Clinical Hospital of Infectious Diseases “Sf. Parascheva”, 700116 Iasi, Romania
5
Faculty of General Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
*
Author to whom correspondence should be addressed.
Children 2023, 10(12), 1879; https://doi.org/10.3390/children10121879
Submission received: 17 October 2023 / Revised: 21 November 2023 / Accepted: 28 November 2023 / Published: 30 November 2023
(This article belongs to the Special Issue Cystic Fibrosis in Children—Monitoring, Complications and New Therapies)
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Abstract

This paper delineates several aspects of cystic fibrosis-related diabetes (CFRD)—a common complication of cystic fibrosis (CF). CFRD exhibits a predilection for older individuals with CF, yet it also extends its influence on children and adolescents. Scientific insights postulate a potential link between CFRD and the aberrant mucus production within the pancreas, thereby culminating in pancreatic insufficiency. This, in turn, perturbs the synthesis of insulin, a pivotal endocrine hormone responsible for the regulation of glycemic levels. Standardized protocols advocate for the systematic screening of CFRD among all individuals with CF, commencing at the age of 10 years using the oral glucose tolerance test (OGTT). Therapeutic modalities encompass insulin therapy, dietary adjustments, and the vigilant monitoring of glycemic parameters. The overarching objective is to maintain blood glucose levels within a targeted range to mitigate the advent of diabetic complications. Untreated or sub-optimally managed CFRD can precipitate a spectrum of deleterious health ramifications, encompassing cardiovascular afflictions, neuropathy, renal dysfunction, and ocular complications.
Keywords: cystic fibrosis; complications; cystic fibrosis-related diabetes; children; adolescents cystic fibrosis; complications; cystic fibrosis-related diabetes; children; adolescents
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MDPI and ACS Style

Anton-Păduraru, D.-T.; Murgu, A.M.; Donos, M.A.; Trofin, F.; Azoicăi, A.N.; Popovici, P.; Stana, A.B.; Gheorghiescu, I.; Trandafir, L.M. An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents. Children 2023, 10, 1879. https://doi.org/10.3390/children10121879

AMA Style

Anton-Păduraru D-T, Murgu AM, Donos MA, Trofin F, Azoicăi AN, Popovici P, Stana AB, Gheorghiescu I, Trandafir LM. An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents. Children. 2023; 10(12):1879. https://doi.org/10.3390/children10121879

Chicago/Turabian Style

Anton-Păduraru, Dana-Teodora, Alina Mariela Murgu, Mădălina Andreea Donos, Felicia Trofin, Alice Nicoleta Azoicăi, Paula Popovici, Aurelian Bogdan Stana, Ionela Gheorghiescu, and Laura Mihaela Trandafir. 2023. "An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents" Children 10, no. 12: 1879. https://doi.org/10.3390/children10121879

APA Style

Anton-Păduraru, D.-T., Murgu, A. M., Donos, M. A., Trofin, F., Azoicăi, A. N., Popovici, P., Stana, A. B., Gheorghiescu, I., & Trandafir, L. M. (2023). An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents. Children, 10(12), 1879. https://doi.org/10.3390/children10121879

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