Unraveling the Complexity of Childhood Polycystic Kidney Disease: A Case Study of Three Sisters
Abstract
:1. Introduction
2. Case Description
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Sister 1 | Sister 2 | Sister 3 | ||
---|---|---|---|---|
Age (years) | 10 | 8 | 4 | |
BMI (kg/m2) | 20.9/87.c. | 18/77.c. | 17/85.c. | |
Urea * (mmol/L) | At diagnosis | 5.9 | 4 | 3.8 |
3 months after | 5.7 | 6.1 | 3.7 | |
9 months after | 6 | 5.1 | 3.8 | |
Serum creatinine ** (umol/L) | At diagnosis | 35 | 30 | 28 |
3 months after | 35 | 32 | 30 | |
9 months after | 37 | 31 | 35 | |
24 h urine protein (mg/m2/h) | At diagnosis | 5 | 4 | 4 |
3 months after | 4 | 4 | 4 | |
9 months after | 5 | 4 | 4 | |
ACR (mg/mL) | At diagnosis | 3 | <3 | <3 |
3 months after | 3 | <3 | <3 | |
9 months after | 3 | <3 | <3 | |
24 h ABPM | At diagnosis | Non-dipping status BP < 90.c. [6] | Normal BP < 90.c. [6] | Home pressure measurements SBP/DBP < 90.c. [6] |
9 months after | Non-dipping status BP < 90.c. [6] | Normal BP < 90.c. [6] | Home pressure measurements SBP/DBP < 90.c. [6] | |
Urinary system ultrasound findings | At diagnosis | RK cyst 20 × 10 mm in the lower pole, several smaller cysts centrally; LK several cystic formations in the lower pole and centrally | RK cyst 8 × 12 mm in the lower pole, 2 smaller cyst centrally; LK several smaller cystic formations in the lower pole | RK cyst 6 × 6 mm in the lower pole, 2 smaller cyst cetrally; LK cyst 12 × 8 mm in the lower pole, several smaller cystic formations |
9 months after | No change compared to the findings at the time of diagnosis | No change compared to the findings at the time of diagnosis | No change compared to the findings at the time of diagnosis | |
Brain MRI angiography using the 3D TOF recording technique | At diagnosis | No aneurysmal expansions on the shown cerebral arteries, stenosis or AV malformations | N/A | No aneurysmal expansions on the shown cerebral arteries, stenosis or AV malformations |
Treatment | None | None | None |
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Trutin, I.; Oletić, L.; Nikuševa-Martić, T. Unraveling the Complexity of Childhood Polycystic Kidney Disease: A Case Study of Three Sisters. Children 2023, 10, 1700. https://doi.org/10.3390/children10101700
Trutin I, Oletić L, Nikuševa-Martić T. Unraveling the Complexity of Childhood Polycystic Kidney Disease: A Case Study of Three Sisters. Children. 2023; 10(10):1700. https://doi.org/10.3390/children10101700
Chicago/Turabian StyleTrutin, Ivana, Lea Oletić, and Tamara Nikuševa-Martić. 2023. "Unraveling the Complexity of Childhood Polycystic Kidney Disease: A Case Study of Three Sisters" Children 10, no. 10: 1700. https://doi.org/10.3390/children10101700
APA StyleTrutin, I., Oletić, L., & Nikuševa-Martić, T. (2023). Unraveling the Complexity of Childhood Polycystic Kidney Disease: A Case Study of Three Sisters. Children, 10(10), 1700. https://doi.org/10.3390/children10101700