Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome
Abstract
:1. Fetal Membranes: A Human Barrier Essential to Childbirth
1.1. Structure of Fetal Membranes
1.2. A Multifunctional Barrier: Different Biological Roles of FM during Pregnancy
2. Inflammation or How Does the FM Rupture Occur Right on Time or Too Early?
2.1. Happy Ending: Well-Balanced Inflammation for a Well-Prepared Rupture of the FM at Term
2.2. Preterm Prelabor Rupture of Fetal Membranes (pPROM)
2.2.1. Definition and Consequences of the pPROM
2.2.2. Pathophysiology of pPROM and Inflammation
3. The Receptor for Advanced Glycation End Products (RAGE)
3.1. RAGE Protein Structure
3.2. RAGE, Ligands and Signaling
3.3. RAGE and Inflammation
3.4. RAGE and Fetal Membranes Rupture
4. Inflammasomes
4.1. What Are Inflammasomes?
4.1.1. The NLRP Inflammasome: The Trio NLRP/ASC/pro-Caspase 1
4.1.2. NLRP Inflammasome Activation
4.2. NLRP Inflammasomes, FM Diseases and pPROM
4.3. Focus on NLRP7
4.4. Does NLRP7 Play a Role in FM Rupture?
5. Conclusion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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NLRP | ASC | Caspase-1 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 12 | 14 | |||
Term Amnion | + | + | + | Ø | Ø | + | + | Ø | + | + | Ø | Ø | Ø | + | + | + |
Term Chorion | + | + | + | Ø | Ø | + | + | Ø | + | + | Ø | + | Ø | + | + | + |
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Choltus, H.; Lavergne, M.; De Sousa Do Outeiro, C.; Coste, K.; Belville, C.; Blanchon, L.; Sapin, V. Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome. Biomedicines 2021, 9, 1123. https://doi.org/10.3390/biomedicines9091123
Choltus H, Lavergne M, De Sousa Do Outeiro C, Coste K, Belville C, Blanchon L, Sapin V. Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome. Biomedicines. 2021; 9(9):1123. https://doi.org/10.3390/biomedicines9091123
Chicago/Turabian StyleCholtus, Helena, Marilyne Lavergne, Coraline De Sousa Do Outeiro, Karen Coste, Corinne Belville, Loïc Blanchon, and Vincent Sapin. 2021. "Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome" Biomedicines 9, no. 9: 1123. https://doi.org/10.3390/biomedicines9091123