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Biomedicines
Volume 9
Issue 7
10.3390/biomedicines9070816
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Review

Thermosensory Transient Receptor Potential Ion Channels and Asthma

by
Oxana Yu. Kytikova
1,*,
Tatyana P. Novgorodtseva
1,
Yulia K. Denisenko
1,
Denis E. Naumov
2,
Tatyana A. Gvozdenko
1 and
Juliy M. Perelman
2
1
Vladivostok Branch of the Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, 690105 Vladivostok, Russia
2
Far Eastern Scientific Center of Physiology and Pathology of Respiration, 675000 Blagoveshchensk, Russia
*
Author to whom correspondence should be addressed.
Biomedicines 2021, 9(7), 816; https://doi.org/10.3390/biomedicines9070816
Submission received: 31 May 2021 / Revised: 9 July 2021 / Accepted: 12 July 2021 / Published: 14 July 2021
(This article belongs to the Section Molecular and Translational Medicine)
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Abstract

Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation of thermosensory TRP channels (vanilloid, ankyrin, and melastatin TRP channels) in the reaction to high and low temperatures and air humidity as well as in the formation of bronchial hyperreactivity and respiratory symptoms accompanying asthma is described. The genetic aspects of the functioning of thermosensory TRP channels are discussed. It is shown that new methods of treatment of asthma exacerbations caused by the influence of temperature and humidity should be based on the regulation of channel activity.
Keywords: asthma; temperature; thermosensory transient receptor potential ion channels; genes asthma; temperature; thermosensory transient receptor potential ion channels; genes

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MDPI and ACS Style

Kytikova, O.Y.; Novgorodtseva, T.P.; Denisenko, Y.K.; Naumov, D.E.; Gvozdenko, T.A.; Perelman, J.M. Thermosensory Transient Receptor Potential Ion Channels and Asthma. Biomedicines 2021, 9, 816. https://doi.org/10.3390/biomedicines9070816

AMA Style

Kytikova OY, Novgorodtseva TP, Denisenko YK, Naumov DE, Gvozdenko TA, Perelman JM. Thermosensory Transient Receptor Potential Ion Channels and Asthma. Biomedicines. 2021; 9(7):816. https://doi.org/10.3390/biomedicines9070816

Chicago/Turabian Style

Kytikova, Oxana Yu., Tatyana P. Novgorodtseva, Yulia K. Denisenko, Denis E. Naumov, Tatyana A. Gvozdenko, and Juliy M. Perelman. 2021. "Thermosensory Transient Receptor Potential Ion Channels and Asthma" Biomedicines 9, no. 7: 816. https://doi.org/10.3390/biomedicines9070816

APA Style

Kytikova, O. Y., Novgorodtseva, T. P., Denisenko, Y. K., Naumov, D. E., Gvozdenko, T. A., & Perelman, J. M. (2021). Thermosensory Transient Receptor Potential Ion Channels and Asthma. Biomedicines, 9(7), 816. https://doi.org/10.3390/biomedicines9070816

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