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Review

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

by 1 and 2,3,4,*
1
School of Physics and Physical Engineering, Qufu Normal University, Qufu 273165, China
2
Key Laboratory of Green Natural Products and Pharmaceutical Intermediates in Colleges and Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China
3
Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China
4
School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China
*
Author to whom correspondence should be addressed.
Academic Editors: Pavel B. Drašar and Fabio Altieri
Biomedicines 2021, 9(6), 689; https://doi.org/10.3390/biomedicines9060689
Received: 18 May 2021 / Revised: 10 June 2021 / Accepted: 15 June 2021 / Published: 18 June 2021
As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases. View Full-Text
Keywords: natural product; SARS-CoV-2; lung cancer; United States Food and Drug Administration-approved drug; natural remedy natural product; SARS-CoV-2; lung cancer; United States Food and Drug Administration-approved drug; natural remedy
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MDPI and ACS Style

Yang, L.; Wang, Z. Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer. Biomedicines 2021, 9, 689. https://doi.org/10.3390/biomedicines9060689

AMA Style

Yang L, Wang Z. Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer. Biomedicines. 2021; 9(6):689. https://doi.org/10.3390/biomedicines9060689

Chicago/Turabian Style

Yang, Liyan, and Zhonglei Wang. 2021. "Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer" Biomedicines 9, no. 6: 689. https://doi.org/10.3390/biomedicines9060689

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