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Review

Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?

by 1,2,* and 3
1
AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland
2
Bulgarian Academy of Sciences, Institute of Metal Science “Acad. A. Balevski”, Shipchenski prohod 67, 1574 Sofia, Bulgaria
3
Institute of Health and Biomedical Innovation, Queensland University of Technology, George Street 2, Brisbane, QLD 4000, Australia
*
Author to whom correspondence should be addressed.
Academic Editors: Alessandro De Vita, Toni Ibrahim, Laura Mercatali and Davide Maria Donati
Biomedicines 2021, 9(6), 691; https://doi.org/10.3390/biomedicines9060691
Received: 12 May 2021 / Revised: 14 June 2021 / Accepted: 16 June 2021 / Published: 18 June 2021
(This article belongs to the Special Issue New Ground-Breaking Strategy in Bone Regeneration)
The impact of the local mechanical environment in the fracture gap on the bone healing process has been extensively investigated. Whilst it is widely accepted that mechanical stimulation is integral to callus formation and secondary bone healing, treatment strategies that aim to harness that potential are rare. In fact, the current clinical practice with an initially partial or non-weight-bearing approach appears to contradict the findings from animal experiments that early mechanical stimulation is critical. Therefore, we posed the question as to whether optimizing the mechanical environment over the course of healing can deliver a clinically significant reduction in fracture healing time. In reviewing the evidence from pre-clinical studies that investigate the influence of mechanics on bone healing, we formulate a hypothesis for the stimulation protocol which has the potential to shorten healing time. The protocol involves confining stimulation predominantly to the proliferative phase of healing and including adequate rest periods between applications of stimulation. View Full-Text
Keywords: fracture healing; bone repair; mechanobiology; implants; rehabilitation fracture healing; bone repair; mechanobiology; implants; rehabilitation
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MDPI and ACS Style

Barcik, J.; Epari, D.R. Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time? Biomedicines 2021, 9, 691. https://doi.org/10.3390/biomedicines9060691

AMA Style

Barcik J, Epari DR. Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time? Biomedicines. 2021; 9(6):691. https://doi.org/10.3390/biomedicines9060691

Chicago/Turabian Style

Barcik, Jan, and Devakara R. Epari. 2021. "Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?" Biomedicines 9, no. 6: 691. https://doi.org/10.3390/biomedicines9060691

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