Next Article in Journal
Comparative Cancer Cell Signaling in Muscle-Invasive Urothelial Carcinoma of the Bladder in Dogs and Humans
Next Article in Special Issue
Bisphosphonates for the Treatment of Calcinosis Cutis—A Retrospective Single-Center Study
Previous Article in Journal
Link between History of Childhood Maltreatment and Emotion Dysregulation in Adults Suffering from Attention Deficit/Hyperactivity Disorder or Borderline Personality Disorder
Previous Article in Special Issue
Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 9
Issue 10
10.3390/biomedicines9101471
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs

by
Iulia Szabo
1,
Laura Muntean
1,2,*,
Tania Crisan
3,4,
Voicu Rednic
5,6,
Claudia Sirbe
1 and
Simona Rednic
1,2
1
Department of Rheumatology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, Romania
2
Department of Rheumatology, County Emergency Hospital Cluj-Napoca, 400000 Cluj-Napoca, Romania
3
Department of Medical Genetics, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, Romania
4
Department of Internal Medicine and Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands
5
Department of Gastroenterology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, Romania
6
Department of Gastroenterology II, “Prof. Dr. Octavian Fodor” Regional Institute of Gastroenterology and Hepatology, 400000 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Biomedicines 2021, 9(10), 1471; https://doi.org/10.3390/biomedicines9101471
Submission received: 12 September 2021 / Revised: 3 October 2021 / Accepted: 8 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Frontiers of Targeted Therapy and Predictors of Treatment Response in Systemic Sclerosis)
Browse Figures
Review Reports Versions Notes

Abstract

Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic marks may be reversible and their differential response to external stimuli could explain the protean clinical manifestations of SSc while offering the opportunity of targeted drug development. Small, non-coding RNA sequences (miRNAs) have demonstrated complex interactions between vasculature, immune activation, and extracellular matrices. Distinct miRNA profiles were identified in SSc skin specimens and blood samples containing a wide variety of dysregulated miRNAs. Their target genes are mainly involved in profibrotic pathways, but new lines of evidence also confirm their participation in impaired angiogenesis and aberrant immune responses. Research approaches focusing on earlier stages of the disease and on differential miRNA expression in various tissues could bring novel insights into SSc pathogenesis and validate the clinical utility of miRNAs as biomarkers and therapeutic targets.
Keywords: systemic sclerosis; pathogenesis; epigenetic mechanisms; miRNAs systemic sclerosis; pathogenesis; epigenetic mechanisms; miRNAs

Share and Cite

MDPI and ACS Style

Szabo, I.; Muntean, L.; Crisan, T.; Rednic, V.; Sirbe, C.; Rednic, S. Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs. Biomedicines 2021, 9, 1471. https://doi.org/10.3390/biomedicines9101471

AMA Style

Szabo I, Muntean L, Crisan T, Rednic V, Sirbe C, Rednic S. Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs. Biomedicines. 2021; 9(10):1471. https://doi.org/10.3390/biomedicines9101471

Chicago/Turabian Style

Szabo, Iulia, Laura Muntean, Tania Crisan, Voicu Rednic, Claudia Sirbe, and Simona Rednic. 2021. "Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs" Biomedicines 9, no. 10: 1471. https://doi.org/10.3390/biomedicines9101471

APA Style

Szabo, I., Muntean, L., Crisan, T., Rednic, V., Sirbe, C., & Rednic, S. (2021). Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs. Biomedicines, 9(10), 1471. https://doi.org/10.3390/biomedicines9101471

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop