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Open AccessReview

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia
Institute for Respiratory Health, University of Western Australia, Crawley, WA 6009, Australia
WA Department of Health, 189 Royal St, East Perth, WA 6004, Australia
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(5), 101;
Received: 17 March 2020 / Revised: 20 April 2020 / Accepted: 23 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue The Interleukin-6 Family in Disease Pathogenesis and Therapy)
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing. View Full-Text
Keywords: IL-6; fibrosis; skin; wounds IL-6; fibrosis; skin; wounds
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Johnson, B.Z.; Stevenson, A.W.; Prêle, C.M.; Fear, M.W.; Wood, F.M. The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing. Biomedicines 2020, 8, 101.

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