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Open AccessReview

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

1
School of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia
2
Institute for Respiratory Health, University of Western Australia, Crawley, WA 6009, Australia
3
WA Department of Health, 189 Royal St, East Perth, WA 6004, Australia
*
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(5), 101; https://doi.org/10.3390/biomedicines8050101
Received: 17 March 2020 / Revised: 20 April 2020 / Accepted: 23 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue The Interleukin-6 Family in Disease Pathogenesis and Therapy)
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing. View Full-Text
Keywords: IL-6; fibrosis; skin; wounds IL-6; fibrosis; skin; wounds
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Johnson, B.Z.; Stevenson, A.W.; Prêle, C.M.; Fear, M.W.; Wood, F.M. The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing. Biomedicines 2020, 8, 101.

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