Next Article in Journal
The Minimal Effect of Linker Length for Fatty Acid Conjugation to a Small Protein on the Serum Half-Life Extension
Next Article in Special Issue
Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients
Previous Article in Journal
Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates
Previous Article in Special Issue
The Lymphoscintigraphic Study of Unpredictable Head and Neck Cutaneous Melanoma Lymphatic Drainage
Open AccessArticle

Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients?

Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(4), 95; https://doi.org/10.3390/biomedicines8040095
Received: 9 March 2020 / Revised: 13 April 2020 / Accepted: 23 April 2020 / Published: 24 April 2020
The aim of this study is to observe the influence of Medication-Related Osteonecrosis of the Jaw (MRONJ) on the physical and mental conditions of cancer patients using a Quality of Life (QoL) questionnaire during regular dental practice measures. Twenty cancer patients (8 males and 12 females) with established MRONJ were enrolled in the “MoMax” (Oral Medicine and Maxillofacial) project of the Department of Oral Sciences and Maxillofacial Surgery at “Sapienza” University of Rome, and were included in the study. The 12-item Short Form Survey was used to evaluate the QoL. Statistical analysis revealed a significant difference for Mental Component Summary (MCS) scores based on age (p = 0.018). The regression analysis revealed that the Physical Component Summary (PCS) scores were negatively influenced by the anti-resorptive medication duration (p = 0.031 and β = −1.137). No significant differences were observed with the other variables considered. The QoL of cancer patients is generally deteriorated and MRONJ may cause a further negative impact. This study highlights the possible need to include psychosocial and physical evaluations in the management process of MRONJ in cancer patients. View Full-Text
Keywords: bisphosphonates; Medication-Related Osteonecrosis of the Jaw; osteonecrosis; quality of life; SF-12 questionnaire bisphosphonates; Medication-Related Osteonecrosis of the Jaw; osteonecrosis; quality of life; SF-12 questionnaire
Show Figures

Figure 1

MDPI and ACS Style

Tenore, G.; Mohsen, A.; Rossi, A.F.; Palaia, G.; Rocchetti, F.; Cassoni, A.; Valentini, V.; Ottolenghi, L.; Polimeni, A.; Romeo, U. Does Medication-Related Osteonecrosis of the Jaw Influence the Quality of Life of Cancer Patients? Biomedicines 2020, 8, 95.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop