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Open AccessArticle

Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients

1
Department Interdisciplinary of Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
2
International Microdentistry Institute (IMI), 50139 Florence, Italy
3
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, 70121 Bari, Italy
4
Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy
5
Biomolecular Diagnostic S.r.l., 50139 Florence, Italy
6
Human Stem Cell’s (HSC), Ho Chi Minh City 70000, Vietnam
7
Department of Multidisciplinary Research Center, Lincoln University, Oakland, CA 94612, USA
8
Pham Chau Trinh University of Medicine, Da Nang City 50000, Vietnam
9
Department of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario “Ernesto Quagliariello”, University of Bari “Aldo Moro”, 70125 Bari, Italy
10
Department of Precision Medicine, University of Campania“Luigi Vanvitelli”, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work as co-first authors.
These authors contributed equally to this work as co-last authors.
Biomedicines 2020, 8(5), 115; https://doi.org/10.3390/biomedicines8050115
Received: 27 March 2020 / Revised: 6 May 2020 / Accepted: 7 May 2020 / Published: 9 May 2020
Chronic periodontitis (CP) is a complex pathology with a significant impact worldwide causing bone loss. Oral dysbiosis is a highly inflammatory condition associated to a long-term insulting infection and represents an underestimated CP key factor associated with an imbalance of pro-inflammatory and anti-inflammatory gene responses. The presence of a single nucleotide polymorphisms (SNPs) in the promoter region of interleukin 10 (IL-10) gene −1082, −819, and −592 was a possible determinant cause. This translational research aimed to provide outcomes on the role of IL-10 gene expression in bone loss diseases in patients affected by CP. Caucasian patients (n = 96) affected by CP were recruited from the Italian population. The subgingival samples were collected using the Bacterial Periodontal Assessment by Biomolecular Diagnostic® and the characterization of a set of 15 bacterial DNA responsible of periodontitis was performed by real-time multiplex PCR. In addition, two viruses, Epstein–Barr Virus (EBV) and Herpes Simplex Virus 1 (HSV-1), and a pathogenic fungi (Candida albicans) were included as a part of our panel. Our results confirmed an existing association between IL-10 gene polymorphisms and polymorphism of tumor necrosis factor alpha (TNFα), interleukin 1α-β-RN (IL-1α-β-RN), collagen type-l alpha (COLIA1), and vitamin D receptor (VDRs) genes in CP. Further studies are needed to improve diagnosis and endorse more effective therapeutic procedures for periodontal disease. View Full-Text
Keywords: chronic periodontitis; oral dysbiosis; IL-10; clinical biochemistry and clinical molecular biology; single nucleotide polymorphisms (SNPs); translational research chronic periodontitis; oral dysbiosis; IL-10; clinical biochemistry and clinical molecular biology; single nucleotide polymorphisms (SNPs); translational research
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Inchingolo, F.; Martelli, F.S.; Gargiulo Isacco, C.; Borsani, E.; Cantore, S.; Corcioli, F.; Boddi, A.; Nguyễn, K.C.; De Vito, D.; Aityan, S.K.; Pham, V.H.; Dipalma, G.; Ballini, A. Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients. Biomedicines 2020, 8, 115.

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