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Volume 8
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Review

Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

by
Abu Bakar
1,2,
Pin-Chuan Yao
3,
Valendriyani Ningrum
2,
Cheng-Tzu Liu
4,5 and
Shih-Chieh Lee
6,*
1
PhD Program of Biotechnology and Industry, Da-Yeh University, Dacun, Changhua 51591, Taiwan
2
School of Dentistry, Baiturrahmah University, Kuranji, Padang 25155, Indonesia
3
Department of Material Science and Engineering, Da-Yeh University, Dacun, Changhua 51591, Taiwan
4
School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
5
Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
6
Department of Food Science and Biotechnology, Da-Yeh University, Dacun, Changhua 51591, Taiwan
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(1), 3; https://doi.org/10.3390/biomedicines8010003
Submission received: 19 November 2019 / Revised: 29 December 2019 / Accepted: 30 December 2019 / Published: 1 January 2020
(This article belongs to the Section Drug Discovery and Development)
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Abstract

The aim of this review was to provide an updated overview of studies on the medical-biological activities of Cinnamomum osmophloeum (C. osmophloeum) in vitro and in vivo and the potential therapeutic use of natural agents prepared from this plant for the alleviation of oral mucositis (OM). Reported articles were collected using web search engine tools. The systematic review was organized according to the preferred reporting items for reviews and meta-analyses (PRISMA) statement. Additional sources were identified through cross-referencing to identify the potential use of C. osmophloeum in the alleviation of OM. The results disclosed that C. osmophloeum is comprised of bioactive ingredients that could act diversely as a reagent in anti-inflammation, antibacterial, antioxidant, anti-hyperglycemic, antidyslipidemia, anti-cancer, renal disease therapy and anti-hyperuricemia capacities. Recent studies revealed that the overall effects on anti-inflammation, wound repair, and the antibacterial and antioxidant activities of its constituents would act as a potential remedy for oral mucositis. Up-to-date in vitro and in vivo studies on the medical-biological activities of C. osmophloeum suggested that C. osmophloeum and its constituents could be promising remedies as adjuvants in OM therapy and warrant further investigation.
Keywords: C. osmophloeum; biological activities; oral mucositis; cinnamaldehyde; linalool C. osmophloeum; biological activities; oral mucositis; cinnamaldehyde; linalool
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MDPI and ACS Style

Bakar, A.; Yao, P.-C.; Ningrum, V.; Liu, C.-T.; Lee, S.-C. Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review. Biomedicines 2020, 8, 3. https://doi.org/10.3390/biomedicines8010003

AMA Style

Bakar A, Yao P-C, Ningrum V, Liu C-T, Lee S-C. Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review. Biomedicines. 2020; 8(1):3. https://doi.org/10.3390/biomedicines8010003

Chicago/Turabian Style

Bakar, Abu, Pin-Chuan Yao, Valendriyani Ningrum, Cheng-Tzu Liu, and Shih-Chieh Lee. 2020. "Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review" Biomedicines 8, no. 1: 3. https://doi.org/10.3390/biomedicines8010003

APA Style

Bakar, A., Yao, P.-C., Ningrum, V., Liu, C.-T., & Lee, S.-C. (2020). Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review. Biomedicines, 8(1), 3. https://doi.org/10.3390/biomedicines8010003

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