Next Article in Journal
Oncostatin M in the Regulation of Connective Tissue Cells and Macrophages in Pulmonary Disease
Previous Article in Journal
Intracellular Localization in Zebrafish Muscle and Conserved Sequence Features Suggest Roles for Gelatinase A Moonlighting in Sarcomere Maintenance
Open AccessArticle

Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study after Literature Review

1
Low Vision Research Centre of Milan, p.zza Sempione 3, 20145 Milan, Italy
2
Department of Sense Organs, Faculty of Medicine and Odontology, Sapienza University of Rome, p.le A. Moro 5, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(4), 94; https://doi.org/10.3390/biomedicines7040094
Received: 10 September 2019 / Revised: 23 November 2019 / Accepted: 26 November 2019 / Published: 30 November 2019
(This article belongs to the Collection Stem Cells and Cancer Therapeutics)
To evaluate whether grafting of autologous mesenchymal cells, adipose-derived stem cells, and platelet-rich plasma into the supracoroideal space by surgical treatment with the Limoli retinal restoration technique (LRRT) can exert a beneficial effect in retinitis pigmentosa (RP) patients. Twenty-one eyes underwent surgery and were divided based on retinal foveal thickness (FT) ≤ 190 or > 190 µm into group A-FT and group B-FT, respectively. The specific LRRT triad was grafted in a deep scleral pocket above the choroid of each eye. At 6-month follow-up, group B showed a non-significant improvement in residual close-up visus and sensitivity at microperimetry compared to group A. After an in-depth review of molecular biology studies concerning degenerative phenomena underlying the etiopathogenesis of retinitis pigmentosa (RP), it was concluded that further research is needed on tapeto-retinal degenerations, both from a clinical and molecular point of view, to obtain better functional results. In particular, it is necessary to increase the number of patients, extend observation timeframes, and treat subjects in the presence of still trophic retinal tissue to allow adequate biochemical and functional catering. View Full-Text
Keywords: autograft; embryonic stem cells (ESCs); growth factor (GF); hereditary retinal disease; induced pluripotent stem cells (iPSCs); limoli retinal restoration technique (LRRT); mesenchymal stem cell (MSC); retinitis pigmentosa; spectral domain-optical coherence tomography (SD-OCT) autograft; embryonic stem cells (ESCs); growth factor (GF); hereditary retinal disease; induced pluripotent stem cells (iPSCs); limoli retinal restoration technique (LRRT); mesenchymal stem cell (MSC); retinitis pigmentosa; spectral domain-optical coherence tomography (SD-OCT)
Show Figures

Figure 1

MDPI and ACS Style

Limoli, P.G.; Vingolo, E.M.; Limoli, C.; Nebbioso, M. Stem Cell Surgery and Growth Factors in Retinitis Pigmentosa Patients: Pilot Study after Literature Review. Biomedicines 2019, 7, 94.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop