Next Article in Journal
Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
Previous Article in Journal
Vindoline—A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes
Open AccessReview

A Classic Herbal Formula Guizhi Fuling Wan for Menopausal Hot Flushes: From Experimental Findings to Clinical Applications

1
School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia
2
School of Science, RMIT University, Melbourne, VIC 3001, Australia
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(3), 60; https://doi.org/10.3390/biomedicines7030060
Received: 30 June 2019 / Revised: 10 August 2019 / Accepted: 15 August 2019 / Published: 18 August 2019
(This article belongs to the Section Natural Compounds in Biomedicine)
A classic herbal formula Guizhi Fuling Wan (GFW) has been used for managing menopausal hot flushes (MHFs), but the evidence across different study types has not been systematically summarized. This project investigated the clinical effects, phytochemistry, pharmacodynamics, and potential mechanisms of actions of GFW on the causative target proteins potentially driving MHFs. Twenty English and Chinese databases were searched for relevant clinical and experimental studies. A total of 12,988 studies were identified, of which 46 were included. Seven clinical studies demonstrated GFW had no statistically significant changes in the frequency and severity of MHFs; however, it could improve peripheral blood flow in the fingertips, jaw, and toes. Thirty-five studies on phytochemistry identified 169 chemical compounds of GFW. Four experimental studies revealed GFW’s therapeutic effects (e.g., normalize calcitonin gene-related peptide (CGRP) level) and potential target protein/cytokine (estrogen receptor beta (ESR2) with genetic variation, CGRP receptor, and interleukin-8) on MHFs. Therapeutic effects across different study types were inconsistent, possibly due to the dose difference and genotype variety of ESR2 in the human population. Further clinical and experimental studies, as well as biochemical investigation on the mechanisms of actions of GFW, are recommended. View Full-Text
Keywords: Cinnamon twig and Poria cocos pill; menopause; literature review; herbal medicine; women’s health; natural products; integrative medicine Cinnamon twig and Poria cocos pill; menopause; literature review; herbal medicine; women’s health; natural products; integrative medicine
Show Figures

Graphical abstract

MDPI and ACS Style

Li, M.; Hung, A.; Li, H.; Yang, A.W.H. A Classic Herbal Formula Guizhi Fuling Wan for Menopausal Hot Flushes: From Experimental Findings to Clinical Applications. Biomedicines 2019, 7, 60.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop