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Stereotactic Body Radiation Therapy in the Management of Upper GI Malignancies

Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA
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Biomedicines 2018, 6(1), 7; https://doi.org/10.3390/biomedicines6010007
Received: 8 November 2017 / Revised: 21 December 2017 / Accepted: 23 December 2017 / Published: 3 January 2018
(This article belongs to the Special Issue Cancer Biomarkers and Targets in Digestive Organs)
The role of external beam radiation therapy (EBRT) in the management of upper gastrointestinal malignancies is constantly evolving. As radiation therapy techniques improve and are able to deliver more ablative doses of radiotherapy while sparing healthy tissue, radiation can be applied to a wider range of clinical scenarios. Stereotactic body radiation therapy (SBRT) allows a high dose of radiation to be delivered to a highly conformal treatment volume in a short amount of time. Another potential advantage of SBRT is its ability to increase tumor immunogenicity, while also having less of an immunosuppressive effect on the patient, as compared to conventionally fractionated radiation therapy. In so doing, SBRT may potentiate the effects of immune therapy when the two treatments are combined, thus improving therapeutic outcomes. This article provides an overview of the role of SBRT in the management of upper gastrointestinal GI malignancies and the emerging data on immune biomarkers and SBRT, with a focus on pancreatic and liver cancer. View Full-Text
Keywords: stereotactic body radiation therapy; immunotherapy; biomarkers stereotactic body radiation therapy; immunotherapy; biomarkers
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Tchelebi, L.; Zaorsky, N.; Mackley, H. Stereotactic Body Radiation Therapy in the Management of Upper GI Malignancies. Biomedicines 2018, 6, 7.

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