Next Article in Journal
Cold Exposure Exacerbates Cardiac Dysfunction in a Model of Heart Failure with Preserved Ejection Fraction in Male and Female C57Bl/6J Mice
Previous Article in Journal
Combined Genetic and Transcriptional Study Unveils the Role of DGAT1 Gene Mutations in Congenital Diarrhea
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 13
Issue 8
10.3390/biomedicines13081899
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery

by
Tianjiao Zeng
1,
Lusi Chen
1,2,
Toru Yoshitomi
1,
Naoki Kawazoe
1,
Yingnan Yang
3 and
Guoping Chen
1,2,*
1
Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Namiki 1-1, Tsukuba 305-0044, Ibaraki, Japan
2
Graduate School of Science and Technology, University of Tsukuba, Tsukuba 305-8577, Ibaraki, Japan
3
Graduate School of Life and Environment Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8572, Ibaraki, Japan
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(8), 1899; https://doi.org/10.3390/biomedicines13081899
Submission received: 27 June 2025 / Revised: 25 July 2025 / Accepted: 1 August 2025 / Published: 4 August 2025
(This article belongs to the Section Drug Discovery, Development and Delivery)
Browse Figures
Versions Notes

Abstract

Tumor treatments have substantially advanced through various approaches, including chemotherapy, radiotherapy, immunotherapy, and gene therapy. However, efficient treatment necessitates overcoming physiological barriers that impede the delivery of therapeutic agents to target sites. Drug delivery systems (DDSs) are a prominent research area, particularly in tumor therapy. This review provides a comprehensive overview of hydrogel-based DDSs for tumor treatment, focusing on the strategies and designs of DDSs based on the unique pathophysiological characteristics of tumors. The design and preparation of hydrogel systems for DDSs are summarized and highlighted. The challenges and opportunities for translating hydrogel-based DDSs into clinical applications are discussed.
Keywords: hydrogel; drug delivery system; antitumor therapy; combination therapy hydrogel; drug delivery system; antitumor therapy; combination therapy

Share and Cite

MDPI and ACS Style

Zeng, T.; Chen, L.; Yoshitomi, T.; Kawazoe, N.; Yang, Y.; Chen, G. Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery. Biomedicines 2025, 13, 1899. https://doi.org/10.3390/biomedicines13081899

AMA Style

Zeng T, Chen L, Yoshitomi T, Kawazoe N, Yang Y, Chen G. Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery. Biomedicines. 2025; 13(8):1899. https://doi.org/10.3390/biomedicines13081899

Chicago/Turabian Style

Zeng, Tianjiao, Lusi Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, and Guoping Chen. 2025. "Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery" Biomedicines 13, no. 8: 1899. https://doi.org/10.3390/biomedicines13081899

APA Style

Zeng, T., Chen, L., Yoshitomi, T., Kawazoe, N., Yang, Y., & Chen, G. (2025). Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery. Biomedicines, 13(8), 1899. https://doi.org/10.3390/biomedicines13081899

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop