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Biomedicines
Volume 13
Issue 7
10.3390/biomedicines13071515
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Communication

Histological Evaluation for Collagen Expression Prior to LVAD Implantation Is Useful to Estimate Weaning Success

by
Maja-Theresa Dieterlen
1,*,
Lea Schreiber
1,
Kristin Klaeske
1,
Joanna Jozwiak-Nozdrzykowska
2,
Michael A. Borger
1,
Alexey Dashkevich
1,
Sandra Eifert
1 and
Michal Nozdrzykowski
1
1
Department of Cardiac Surgery, HELIOS Clinic, Heart Center Leipzig, University Hospital Leipzig, 04289 Leipzig, Germany
2
Department of Cardiology, Heart Center Leipzig, Leipzig University, 04289 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Biomedicines 2025, 13(7), 1515; https://doi.org/10.3390/biomedicines13071515
Submission received: 9 May 2025 / Revised: 12 June 2025 / Accepted: 18 June 2025 / Published: 20 June 2025
(This article belongs to the Special Issue Advances in the Pathogenesis and Treatment of Heart Failure and Cardiomyopathy)
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Abstract

Introduction: The implantation of a left ventricular assist device (LVAD) is a life-saving therapeutic option for patients with advanced heart failure. The treatment goal has to be determined prior to LVAD implantation. However, prognostic evaluation for defining the treatment goal could be improved for a time- and cost-effective medical treatment. Methods: Our study comprised seven patients who were weaned from LVAD (recovery group) and a control group without weaning (non-recovery group; n = 7). Myocardial tissue was analysed for connective tissue content by Masson–Goldner trichrome staining and for collagen I and collagen III expression by quantitative real-time PCR and immunohistochemistry. Results: The histological evaluation revealed comparable values for the percentage of total connective tissue (non-recovery: 46.3% [95% CI: 15.9–76.7], recovery: 43.4% [95% CI: 13.7–73.2], p = 0.43). mRNA expression analysis for collagen I and III expression could not detect a difference in collagen I (p = 0.16) and collagen III expression (p = 0.12) between the non-recovery and the recovery group. Immunohistochemical staining revealed that the percentages of collagen I (p = 0.05) and of collagen III (p = 0.01) were reduced in patients who do not recover compared to patients who recover under LVAD support. Conclusions: Our data indicate that histological evaluation for collagen expression prior to LVAD implantation could detect differences in the collagen content that could be helpful for estimating the weaning success.
Keywords: collagen; left ventricular assist device; weaning; recovery; histology collagen; left ventricular assist device; weaning; recovery; histology

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MDPI and ACS Style

Dieterlen, M.-T.; Schreiber, L.; Klaeske, K.; Jozwiak-Nozdrzykowska, J.; Borger, M.A.; Dashkevich, A.; Eifert, S.; Nozdrzykowski, M. Histological Evaluation for Collagen Expression Prior to LVAD Implantation Is Useful to Estimate Weaning Success. Biomedicines 2025, 13, 1515. https://doi.org/10.3390/biomedicines13071515

AMA Style

Dieterlen M-T, Schreiber L, Klaeske K, Jozwiak-Nozdrzykowska J, Borger MA, Dashkevich A, Eifert S, Nozdrzykowski M. Histological Evaluation for Collagen Expression Prior to LVAD Implantation Is Useful to Estimate Weaning Success. Biomedicines. 2025; 13(7):1515. https://doi.org/10.3390/biomedicines13071515

Chicago/Turabian Style

Dieterlen, Maja-Theresa, Lea Schreiber, Kristin Klaeske, Joanna Jozwiak-Nozdrzykowska, Michael A. Borger, Alexey Dashkevich, Sandra Eifert, and Michal Nozdrzykowski. 2025. "Histological Evaluation for Collagen Expression Prior to LVAD Implantation Is Useful to Estimate Weaning Success" Biomedicines 13, no. 7: 1515. https://doi.org/10.3390/biomedicines13071515

APA Style

Dieterlen, M.-T., Schreiber, L., Klaeske, K., Jozwiak-Nozdrzykowska, J., Borger, M. A., Dashkevich, A., Eifert, S., & Nozdrzykowski, M. (2025). Histological Evaluation for Collagen Expression Prior to LVAD Implantation Is Useful to Estimate Weaning Success. Biomedicines, 13(7), 1515. https://doi.org/10.3390/biomedicines13071515

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