Next Article in Journal
Comparison of Multiple Carbapenemase Tests Based on an Unbiased Colony-Selection Method
Next Article in Special Issue
Structural Basis for Chemerin Recognition and Signaling Through Its Receptors
Previous Article in Journal
Human Serum, Following Absorption of Fish Cartilage Hydrolysate, Promotes Dermal Fibroblast Healing through Anti-Inflammatory and Immunomodulatory Proteins
Previous Article in Special Issue
Chemerin Levels in COVID-19 Are More Affected by Underlying Diseases than by the Virus Infection Itself
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 9
10.3390/biomedicines12092133
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction

by
Andreas Mitsis
1,*,
Elina Khattab
1,
Michael Myrianthefs
1,
Stergios Tzikas
2,
Nikolaos P. E. Kadoglou
3,
Nikolaos Fragakis
4,
Antonios Ziakas
5 and
George Kassimis
4
1
Cardiology Department, Nicosia General Hospital, State Health Services Organization, Nicosia 2029, Cyprus
2
Third Department of Cardiology, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
3
Medical School, University of Cyprus, Nicosia 2115, Cyprus
4
Second Department of Cardiology, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
5
First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(9), 2133; https://doi.org/10.3390/biomedicines12092133
Submission received: 24 August 2024 / Revised: 15 September 2024 / Accepted: 18 September 2024 / Published: 20 September 2024
(This article belongs to the Special Issue The Role of Chemerin in Human Disease—2nd Edition)
Browse Figure
Versions Notes

Abstract

Chemerin, an adipokine known for its role in adipogenesis and inflammation, has emerged as a significant biomarker in cardiovascular diseases, including acute myocardial infarction (AMI). Recent studies have highlighted chemerin’s involvement in the pathophysiological processes of coronary artery disease (CAD), where it modulates inflammatory responses, endothelial function, and vascular remodelling. Elevated levels of chemerin have been associated with adverse cardiovascular outcomes, including increased myocardial injury, left ventricular dysfunction, and heightened inflammatory states post-AMI. This manuscript aims to provide a comprehensive review of the current understanding of chemerin’s role in AMI, detailing its molecular mechanisms, clinical implications, and potential as a biomarker for diagnosis and prognosis. Additionally, we explore the therapeutic prospects of targeting chemerin pathways to mitigate myocardial damage and improve clinical outcomes in AMI patients. By synthesizing the latest research findings, this review seeks to elucidate the multifaceted role of chemerin in AMI and its promise as a target for innovative therapeutic strategies.
Keywords: acute myocardial infarction; adipokines; atherosclerosis; biomarkers; cardiovascular disease; cardiovascular risk factors; chemerin; coronary artery disease; inflammation; pro-inflammatory cytokines acute myocardial infarction; adipokines; atherosclerosis; biomarkers; cardiovascular disease; cardiovascular risk factors; chemerin; coronary artery disease; inflammation; pro-inflammatory cytokines

Share and Cite

MDPI and ACS Style

Mitsis, A.; Khattab, E.; Myrianthefs, M.; Tzikas, S.; Kadoglou, N.P.E.; Fragakis, N.; Ziakas, A.; Kassimis, G. Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction. Biomedicines 2024, 12, 2133. https://doi.org/10.3390/biomedicines12092133

AMA Style

Mitsis A, Khattab E, Myrianthefs M, Tzikas S, Kadoglou NPE, Fragakis N, Ziakas A, Kassimis G. Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction. Biomedicines. 2024; 12(9):2133. https://doi.org/10.3390/biomedicines12092133

Chicago/Turabian Style

Mitsis, Andreas, Elina Khattab, Michael Myrianthefs, Stergios Tzikas, Nikolaos P. E. Kadoglou, Nikolaos Fragakis, Antonios Ziakas, and George Kassimis. 2024. "Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction" Biomedicines 12, no. 9: 2133. https://doi.org/10.3390/biomedicines12092133

APA Style

Mitsis, A., Khattab, E., Myrianthefs, M., Tzikas, S., Kadoglou, N. P. E., Fragakis, N., Ziakas, A., & Kassimis, G. (2024). Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction. Biomedicines, 12(9), 2133. https://doi.org/10.3390/biomedicines12092133

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop