Checkpoint Inhibitors and Induction of Celiac Disease-like Condition

Round 1

Reviewer 1 Report

Very interesting topic as side effects of moderd drugs are of great concern. Celiac disease triggered by new medications is not well known possibility and therefore spreading this knowledge is very needed. 

Author Response

Hello

I was asked to reduce my references to a maximum of ten self-references

The reference number was reduced by 23 publications, from a total of 162 to 139 references

Best regards

Prof. Aaron Lerner , corresponding author 

Author Response File: Author Response.doc

Reviewer 2 Report

This manuscript describes the background of the mergence of autoimmune disease induced by the use of immune check point inhibitors. This is very well elaborated and yields information even for a reader who is not so familiar with this new type of tumour therapy.

My only concern is the title of the manuscript. In the 13 patients who are the background of this manuscript, there is indeed a disease with villous atrophy and intraepithelial lymphocyte infiltration. However, this condition cannot be regarded as celiac disease, as the authors mention themselves. Important criteria for celiac disease are not fulfilled.

Therefore, I suggest to change the title to:  Checkpoint inhibitors and induction of a celiac disease - like condition

Author Response

Hello, thanks for your valuable comment.

The title was changed

English and style were improved

Reviewer 3 Report

Authors review an interesting topic, as it is the adverse effects of immune checkpoint inhibitors in oncological therapy resistant cancer. The issue is receiving increasing attention in the literature, so readers will very much appreciate it. The structure of the review is very well structured and organized. In my opinion, the manuscript is suitable for publication.

Author Response

Hello, thanks for your comments

English and style were improved