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Biomedicines
Volume 10
Issue 1
10.3390/biomedicines10010156
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Review

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

by
Maria Radanova
1,2,*,
Mariya Levkova
3,
Galya Mihaylova
1,
Rostislav Manev
4,5,
Margarita Maneva
4,5,
Rossen Hadgiev
6,
Nikolay Conev
4,5 and
Ivan Donev
7
1
Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria
2
Laboratory of Molecular Pathology, University Hospital “St. Marina”, 9000 Varna, Bulgaria
3
Department of Medical Genetics, Medical University of Varna, 9000 Varna, Bulgaria
4
Department of Oncology, Medical University of Varna, 9000 Varna, Bulgaria
5
Clinic of Medical Oncology, University Hospital “St. Marina”, 9000 Varna, Bulgaria
6
Department of Anatomy and Histology, Pathology and Forensic Medicine, Sofia University “St. Kliment Ohridski”, 1000 Sofia, Bulgaria
7
Clinic of Medical Oncology, Hospital “Nadezhda”, 1000 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Biomedicines 2022, 10(1), 156; https://doi.org/10.3390/biomedicines10010156
Submission received: 21 December 2021 / Revised: 9 January 2022 / Accepted: 10 January 2022 / Published: 12 January 2022
(This article belongs to the Special Issue MicroRNAs, tRNA Fragments, and Circular RNAs: Pivotal Regulators of Gene Expression and Their Roles in Human Diseases)
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Abstract

There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.
Keywords: single nucleotide polymorphism; SNP; miRNA; colorectal cancer single nucleotide polymorphism; SNP; miRNA; colorectal cancer

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MDPI and ACS Style

Radanova, M.; Levkova, M.; Mihaylova, G.; Manev, R.; Maneva, M.; Hadgiev, R.; Conev, N.; Donev, I. Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis. Biomedicines 2022, 10, 156. https://doi.org/10.3390/biomedicines10010156

AMA Style

Radanova M, Levkova M, Mihaylova G, Manev R, Maneva M, Hadgiev R, Conev N, Donev I. Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis. Biomedicines. 2022; 10(1):156. https://doi.org/10.3390/biomedicines10010156

Chicago/Turabian Style

Radanova, Maria, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, and Ivan Donev. 2022. "Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis" Biomedicines 10, no. 1: 156. https://doi.org/10.3390/biomedicines10010156

APA Style

Radanova, M., Levkova, M., Mihaylova, G., Manev, R., Maneva, M., Hadgiev, R., Conev, N., & Donev, I. (2022). Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis. Biomedicines, 10(1), 156. https://doi.org/10.3390/biomedicines10010156

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