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Biomedicines
Volume 10
Issue 2
10.3390/biomedicines10020428
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Review

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

by
Assiya Kussainova
1,2,
Olga Bulgakova
2,
Akmaral Aripova
2,
Zumama Khalid
1,
Rakhmetkazhi Bersimbaev
2,* and
Alberto Izzotti
3,4,*
1
Department of Health Sciences, University of Genova, Via Pastore 1, 16132 Genoa, Italy
2
Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Nur-Sultan, Akmola 010008, Kazakhstan
3
Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy
4
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
*
Authors to whom correspondence should be addressed.
Biomedicines 2022, 10(2), 428; https://doi.org/10.3390/biomedicines10020428
Submission received: 27 December 2021 / Revised: 7 February 2022 / Accepted: 7 February 2022 / Published: 11 February 2022
(This article belongs to the Special Issue MicroRNAs, tRNA Fragments, and Circular RNAs: Pivotal Regulators of Gene Expression and Their Roles in Human Diseases)
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Abstract

MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure.
Keywords: radon; microRNA; mitochondrial microRNA; lung cancer radon; microRNA; mitochondrial microRNA; lung cancer

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MDPI and ACS Style

Kussainova, A.; Bulgakova, O.; Aripova, A.; Khalid, Z.; Bersimbaev, R.; Izzotti, A. The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer. Biomedicines 2022, 10, 428. https://doi.org/10.3390/biomedicines10020428

AMA Style

Kussainova A, Bulgakova O, Aripova A, Khalid Z, Bersimbaev R, Izzotti A. The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer. Biomedicines. 2022; 10(2):428. https://doi.org/10.3390/biomedicines10020428

Chicago/Turabian Style

Kussainova, Assiya, Olga Bulgakova, Akmaral Aripova, Zumama Khalid, Rakhmetkazhi Bersimbaev, and Alberto Izzotti. 2022. "The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer" Biomedicines 10, no. 2: 428. https://doi.org/10.3390/biomedicines10020428

APA Style

Kussainova, A., Bulgakova, O., Aripova, A., Khalid, Z., Bersimbaev, R., & Izzotti, A. (2022). The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer. Biomedicines, 10(2), 428. https://doi.org/10.3390/biomedicines10020428

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