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Surface Functionalization of Cotton Fabric with Fluorescent Dendrimers, Spectral Characterization, Cytotoxicity, Antimicrobial and Antitumor Activity

1
Faculty of Medicine, Sofia University “St. Kliment Ohridski”, 1407 Sofia, Bulgaria
2
Faculty of Chemical Technology, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria
3
The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
4
Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Bl. 25, 1113 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Chemosensors 2019, 7(2), 17; https://doi.org/10.3390/chemosensors7020017
Received: 6 February 2019 / Revised: 21 March 2019 / Accepted: 25 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue New insides in Fluorescent and Colorimetric Probes)
Poly(propylenimine) dendrimers from first and third generations modified with 1,8-naphthalimide units and their Zn(II) complexes have been investigated by absorption and fluorescence spectroscopy. These dendrimers have been deposited on a cotton cloth by the extraction method, producing yellow-colored textile materials. They have been characterized by defining their color coordinates L*a*b*, XYZ and xy. The antimicrobial activity of dendrimers has been investigated in vitro against model gram-positive and gram-negative bacteria and yeasts. Being deposited onto the surface of cotton fabric, the studied dendrimers reduced bacterial growth and prevented the formation of bacterial biofilm. Anticancer and cytotoxicity activities have also been performed against HeLa and Lep-3 human tumor cell lines as model systems. View Full-Text
Keywords: dendrimer; metallodendrimer; 1,8-naphthalimide; antimicrobial activity; anticancer activity dendrimer; metallodendrimer; 1,8-naphthalimide; antimicrobial activity; anticancer activity
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Grabchev, I.; Staneva, D.; Vasileva-Tonkova, E.; Alexandrova, R. Surface Functionalization of Cotton Fabric with Fluorescent Dendrimers, Spectral Characterization, Cytotoxicity, Antimicrobial and Antitumor Activity. Chemosensors 2019, 7, 17.

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