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Review

Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis

1
Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic
2
Faculty of Sport Sciences, University of Murcia, 30720 Murcia, Spain
3
Centre of Expertise Longevity and Long Term Care and Centre of Gerontology, Faculty of Humanities, Charles University, 18200 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Filipe Manuel Clemente
Healthcare 2021, 9(11), 1438; https://doi.org/10.3390/healthcare9111438
Received: 27 September 2021 / Revised: 21 October 2021 / Accepted: 22 October 2021 / Published: 25 October 2021
(This article belongs to the Special Issue Sport and Exercise Medicine)
Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27–0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits. View Full-Text
Keywords: physical activity; myokines; health; intervention physical activity; myokines; health; intervention
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MDPI and ACS Style

Jandova, T.; Buendía-Romero, A.; Polanska, H.; Hola, V.; Rihova, M.; Vetrovsky, T.; Courel-Ibáñez, J.; Steffl, M. Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis. Healthcare 2021, 9, 1438. https://doi.org/10.3390/healthcare9111438

AMA Style

Jandova T, Buendía-Romero A, Polanska H, Hola V, Rihova M, Vetrovsky T, Courel-Ibáñez J, Steffl M. Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis. Healthcare. 2021; 9(11):1438. https://doi.org/10.3390/healthcare9111438

Chicago/Turabian Style

Jandova, Tereza, Angel Buendía-Romero, Hana Polanska, Veronika Hola, Marcela Rihova, Tomas Vetrovsky, Javier Courel-Ibáñez, and Michal Steffl. 2021. "Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis" Healthcare 9, no. 11: 1438. https://doi.org/10.3390/healthcare9111438

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