Patient Satisfaction with CAD/CAM 3D-Printed Complete Dentures: A Systematic Analysis of the Clinical Studies

Objectives: This systematic review compares computer-aided design and computer-aided manufacturing (CAD/CAM) 3D-printed complete dentures (CDs) with conventional ones in terms of patient satisfaction. Methods: The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting criteria for systematic reviews were followed in conducting this systematic review. The study question was “What are the patient satisfaction outcomes of 3D-printed versus conventional CDs in edentulous patients?” according to the population, intervention, comparison, and outcome (PICO) framework. A comprehensive electronic search was conducted across three databases (PubMed/Medline, Web of Science core collection, and Scopus; last update: 18 August 2024) to obtain clinical trials that compared traditional and 3D-printed CDs. The retrieved articles were screened, their data were extracted, and their quality was evaluated. Results: The initial search retrieved 803 publications; 12 were chosen for a thorough review, and 5 of them—4 randomized cross-over studies and 1 randomized three-parallel arm study—met the requirements for this systematic review. One study showed significant differences in five of nine patient denture satisfaction domains, positively favoring the conventional CDs. Two studies showed non-significant differences in satisfaction domains between the conventional and 3D-printed groups, except for aesthetics and pronunciation. On the contrary, the satisfaction scores in two other studies showed no significant difference between the conventional and 3D-printed denture groups. Conclusions: The analysis of the included studies and evidence gathered demonstrates that CAD/CAM 3D-printed CDs seem to be comparable with conventional CDs in terms of overall patient satisfaction; however, 3D-printed CDs generate some concerns related to aesthetics and speech.