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Volume 13
Issue 23
10.3390/healthcare13233079
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Systematic Review

Effects of Resistance Training on Motor and Cognitive Function in Older Adults with Alzheimer’s Disease: A Systematic Review

by
Maria Fernanda Serna-Orozco
1,2,
Stefania Pitto-Bedoya
2,
Jhoan Sebastián Salazar-Goyes
2,
Sebastián Figueroa-Zúñiga
2,
Luisa María Martínez-Muñoz
3 and
Jennifer Jaramillo-Losada
2,4,*
1
Research Group Biomateriales y Biotecnología (BEO), Universidad Santiago de Cali, Cali 760035, Colombia
2
Physiotherapy Program, Faculty of Health, Universidad Santiago de Cali, Cali 760035, Colombia
3
Programa de Fisioterapia, Grupo de Investigación Ejercicio y Salud Cardiopulmonar (GIESC), Universidad del Valle, Cali 760035, Colombia
4
Physiotherapy Program, Faculty of Health, Salud y Movimiento Grupo de Investigación, Universidad Santiago de Cali, Cali 760035, Colombia
*
Author to whom correspondence should be addressed.
Healthcare 2025, 13(23), 3079; https://doi.org/10.3390/healthcare13233079
Submission received: 30 September 2025 / Revised: 18 November 2025 / Accepted: 25 November 2025 / Published: 26 November 2025
(This article belongs to the Special Issue Advances in Chronic Disease Management, Rehabilitation, and Health Outcomes)
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Abstract

Background/Objectives: This systematic review aimed to determine the effects of resistance training on cognitive and motor function in older adults diagnosed with Alzheimer’s disease (AD). Methods: The review followed PRISMA guidelines. A comprehensive search strategy was applied across MEDLINE (OVID), SCOPUS, Web of Science, LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL). The included studies were experimental, quasi-experimental, cohort, case–control, and cross-sectional designs. Exclusion criteria included studies in animals, pediatric populations, individuals with other types of dementia, Down syndrome, or other neurodegenerative diseases. Conclusions: Resistance training appears to exert beneficial effects on both motor and cognitive functions in older adults with AD. However, the development of standardized, individualized exercise protocols is essential to optimize therapeutic outcomes
Keywords: Alzheimer’s disease; motor function; cognitive function; muscle strength; physical exercise Alzheimer’s disease; motor function; cognitive function; muscle strength; physical exercise
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MDPI and ACS Style

Serna-Orozco, M.F.; Pitto-Bedoya, S.; Salazar-Goyes, J.S.; Figueroa-Zúñiga, S.; Martínez-Muñoz, L.M.; Jaramillo-Losada, J. Effects of Resistance Training on Motor and Cognitive Function in Older Adults with Alzheimer’s Disease: A Systematic Review. Healthcare 2025, 13, 3079. https://doi.org/10.3390/healthcare13233079

AMA Style

Serna-Orozco MF, Pitto-Bedoya S, Salazar-Goyes JS, Figueroa-Zúñiga S, Martínez-Muñoz LM, Jaramillo-Losada J. Effects of Resistance Training on Motor and Cognitive Function in Older Adults with Alzheimer’s Disease: A Systematic Review. Healthcare. 2025; 13(23):3079. https://doi.org/10.3390/healthcare13233079

Chicago/Turabian Style

Serna-Orozco, Maria Fernanda, Stefania Pitto-Bedoya, Jhoan Sebastián Salazar-Goyes, Sebastián Figueroa-Zúñiga, Luisa María Martínez-Muñoz, and Jennifer Jaramillo-Losada. 2025. "Effects of Resistance Training on Motor and Cognitive Function in Older Adults with Alzheimer’s Disease: A Systematic Review" Healthcare 13, no. 23: 3079. https://doi.org/10.3390/healthcare13233079

APA Style

Serna-Orozco, M. F., Pitto-Bedoya, S., Salazar-Goyes, J. S., Figueroa-Zúñiga, S., Martínez-Muñoz, L. M., & Jaramillo-Losada, J. (2025). Effects of Resistance Training on Motor and Cognitive Function in Older Adults with Alzheimer’s Disease: A Systematic Review. Healthcare, 13(23), 3079. https://doi.org/10.3390/healthcare13233079

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