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Correction published on 7 November 2024, see Healthcare 2024, 12(22), 2219.
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Systematic Review

The Efficacy of Ketamine for Acute and Chronic Pain in Patients with Cancer: A Systematic Review of Randomized Controlled Trials

by
Leila Azari
1,*,
Homa Hemati
2,
Ronia Tavasolian
3,
Sareh Shahdab
2,
Stephanie M. Tomlinson
1,
Margarita Bobonis Babilonia
4,5,6,
Jeffrey Huang
7,
Danielle B. Tometich
8,
Kea Turner
6,8,
Kimia Saleh Anaraki
9,
Heather S. L. Jim
6,8 and
Amir Alishahi Tabriz
6,8
1
Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA
2
College of Pharmacy, Tehran University of Medical Sciences, Tehran 1416753955, Iran
3
Department of Clinical Science and Nutrition, University of Chester, Chester CH1 4BJ, UK
4
Supportive Care Medicine Department, Behavioral Medicine Services, Moffitt Cancer Center, Tampa, FL 33612, USA
5
Department of Psychiatry and Behavioral Medicine, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA
6
Department of Oncological Sciences, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA
7
Department of Anesthesiology, Moffitt Cancer Center, Tampa, FL 33612, USA
8
Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33612, USA
9
Department of Internal Medicine, University of Maryland Capital Region, Largo, MD 20774, USA
*
Author to whom correspondence should be addressed.
Healthcare 2024, 12(16), 1560; https://doi.org/10.3390/healthcare12161560
Submission received: 1 July 2024 / Revised: 31 July 2024 / Accepted: 2 August 2024 / Published: 6 August 2024 / Corrected: 7 November 2024
(This article belongs to the Special Issue Pain Management Practice and Research)
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Abstract

Managing cancer-related pain poses significant challenges, prompting research into alternative approaches such as ketamine. This systematic review aims to analyze and summarize the impact of ketamine as an adjuvant to opioid therapy for cancer-related pain. We conducted a literature review in MEDLINE, EMBASE, and Scopus from 1 January 1982 to 20 October 2023. Abstracts were screened against inclusion criteria, and eligible studies underwent a full-text review. Data was extracted from the included studies, and a framework analysis approach summarized the evidence regarding ketamine’s use in patients with cancer. A total of 21 randomized clinical trials were included, and the quality of all the included studies was good or fair. Significant improvements in pain scores and reduced morphine consumption were consistently observed with intravenous ketamine administration for postoperative pain control, particularly when combined with other analgesics such as morphine. Ketamine was less effective when used as an analgesic for chronic pain management, with several studies on neuropathic pain or chemotherapy-induced neuropathy finding minimal significant effect on reduction of pain scores or morphine requirements. The efficacy of ketamine in pain management appears to depend on factors such as dosage, route of administration, and patient population.
Keywords: ketamine; pain; cancer; oncology; refractory cancer pain ketamine; pain; cancer; oncology; refractory cancer pain

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MDPI and ACS Style

Azari, L.; Hemati, H.; Tavasolian, R.; Shahdab, S.; Tomlinson, S.M.; Babilonia, M.B.; Huang, J.; Tometich, D.B.; Turner, K.; Anaraki, K.S.; et al. The Efficacy of Ketamine for Acute and Chronic Pain in Patients with Cancer: A Systematic Review of Randomized Controlled Trials. Healthcare 2024, 12, 1560. https://doi.org/10.3390/healthcare12161560

AMA Style

Azari L, Hemati H, Tavasolian R, Shahdab S, Tomlinson SM, Babilonia MB, Huang J, Tometich DB, Turner K, Anaraki KS, et al. The Efficacy of Ketamine for Acute and Chronic Pain in Patients with Cancer: A Systematic Review of Randomized Controlled Trials. Healthcare. 2024; 12(16):1560. https://doi.org/10.3390/healthcare12161560

Chicago/Turabian Style

Azari, Leila, Homa Hemati, Ronia Tavasolian, Sareh Shahdab, Stephanie M. Tomlinson, Margarita Bobonis Babilonia, Jeffrey Huang, Danielle B. Tometich, Kea Turner, Kimia Saleh Anaraki, and et al. 2024. "The Efficacy of Ketamine for Acute and Chronic Pain in Patients with Cancer: A Systematic Review of Randomized Controlled Trials" Healthcare 12, no. 16: 1560. https://doi.org/10.3390/healthcare12161560

APA Style

Azari, L., Hemati, H., Tavasolian, R., Shahdab, S., Tomlinson, S. M., Babilonia, M. B., Huang, J., Tometich, D. B., Turner, K., Anaraki, K. S., Jim, H. S. L., & Tabriz, A. A. (2024). The Efficacy of Ketamine for Acute and Chronic Pain in Patients with Cancer: A Systematic Review of Randomized Controlled Trials. Healthcare, 12(16), 1560. https://doi.org/10.3390/healthcare12161560

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