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From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction

1
Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
2
School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
3
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Proteomes 2018, 6(4), 50; https://doi.org/10.3390/proteomes6040050
Received: 13 November 2018 / Revised: 5 December 2018 / Accepted: 7 December 2018 / Published: 9 December 2018
(This article belongs to the Special Issue Neuroproteomics)
Drug addiction is a complex disorder driven by dysregulation in molecular signaling across several different brain regions. Limited therapeutic options currently exist for treating drug addiction and related psychiatric disorders in clinical populations, largely due to our incomplete understanding of the molecular pathways that influence addiction pathology. Recent work provides strong evidence that addiction-related behaviors emerge from the convergence of many subtle changes in molecular signaling networks that include neuropeptides (neuropeptidome), protein-protein interactions (interactome) and post-translational modifications such as protein phosphorylation (phosphoproteome). Advancements in mass spectrometry methodology are well positioned to identify these novel molecular underpinnings of addiction and further translate these findings into druggable targets for therapeutic development. In this review, we provide a general perspective of the utility of novel mass spectrometry-based approaches for addressing critical questions in addiction neuroscience, highlighting recent innovative studies that exemplify how functional assessments of the neuroproteome can provide insight into the mechanisms of drug addiction. View Full-Text
Keywords: neuroproteome; drug abuse; neuropeptidomics; phosphorylation; interactome neuroproteome; drug abuse; neuropeptidomics; phosphorylation; interactome
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Natividad, L.A.; Buczynski, M.W.; McClatchy, D.B.; Yates, J.R., III. From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction. Proteomes 2018, 6, 50.

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