Next Article in Journal
Perceived Benefit of Immunization-Trained Technicians in the Pharmacy Workflow
Previous Article in Journal
Evaluation of Medication Error Incident Reports at a Tertiary Care Hospital
Previous Article in Special Issue
Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting
Open AccessReview

Glycopeptide Hypersensitivity and Adverse Reactions

Department of Pharmacy Practice, Midwestern University College of Pharmacy-Glendale, Glendale, AZ 85308, USA
Department of Pharmacy Services, UC Davis Health, Sacramento, CA 95817, USA
Department of Pharmacy Services, Mercy Gilbert Medical Center, Dignity Health, Gilbert, AZ 85297, USA
Author to whom correspondence should be addressed.
Pharmacy 2020, 8(2), 70;
Received: 5 January 2020 / Revised: 23 March 2020 / Accepted: 18 April 2020 / Published: 21 April 2020
(This article belongs to the Special Issue Antibiotic Allergies)
Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most commonly prescribed parenteral antimicrobials. Parenteral glycopeptides are first-line therapy for severe MRSA infections; however, oral vancomycin is used as a first-line treatment of Clostridioides difficile infections. Also, we currently have the longer-acting lipoglycopeptides, such as dalbavancin, oritavancin, and telavancin to our armamentarium for the treatment of MRSA infections. Lastly, vancomycin is often used as an alternative treatment for patients with β-lactam hypersensitivity. Common adverse effects associated with glycopeptide use include nephrotoxicity, ototoxicity, and Redman Syndrome (RMS). The RMS is often mistaken for a true allergy; however, it is a histamine-related infusion reaction rather than a true immunoglobulin E (IgE)-mediated allergic reaction. Although hypersensitivity to glycopeptides is rare, both immune-mediated and delayed reactions have been reported in the literature. We describe the various types of glycopeptide hypersensitivity reactions associated with glycopeptides and lipoglycopeptides, including IgE-mediated reactions, RMS, and linear immunoglobulin A bullous dermatosis, as well as describe cross-reactivity with other glycopeptides. View Full-Text
Keywords: dalbavancin; glycopeptides; hypersensitivity; lipoglycopeptides; oritavancin; Redman Syndrome; teicoplanin; telavancin; vancomycin dalbavancin; glycopeptides; hypersensitivity; lipoglycopeptides; oritavancin; Redman Syndrome; teicoplanin; telavancin; vancomycin
MDPI and ACS Style

Huang, V.; Clayton, N.A.; Welker, K.H. Glycopeptide Hypersensitivity and Adverse Reactions. Pharmacy 2020, 8, 70.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop