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Open AccessReview

Principles of Drug Dosing in Sustained Low Efficiency Dialysis (SLED) and Review of Antimicrobial Dosing Literature

by Paula Brown 1,2 and Marisa Battistella 1,2,*
1
Pharmacy Department, University Health Network, Toronto, ON M4G 2C4, Canada
2
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada
*
Author to whom correspondence should be addressed.
Pharmacy 2020, 8(1), 33; https://doi.org/10.3390/pharmacy8010033
Received: 19 December 2019 / Revised: 17 February 2020 / Accepted: 6 March 2020 / Published: 9 March 2020
(This article belongs to the Special Issue Pharmacokinetics of Drugs and Dosing in Kidney Disease)
The use of sustained low-efficiency dialysis (SLED) as a renal replacement modality has increased in critically ill patients with both acute kidney injury (AKI) and hemodynamic instability. Unfortunately, there is a paucity of data regarding the appropriate dosing of medications for patients undergoing SLED. Dose adjustment in SLED often requires interpretation of pharmacodynamics and pharmacokinetic factors and extrapolation based on dosing recommendations from other modes of renal replacement therapy (RRT). This review summarizes published trials of antimicrobial dose adjustment in SLED and discusses pharmacokinetic considerations specific to medication dosing in SLED. Preliminary recommendation is provided on selection of appropriate dosing for medications where published literature is unavailable. View Full-Text
Keywords: acute kidney injury; AKI; sustained low efficiency dialysis; sled; pharmacokinetics; antimicrobials acute kidney injury; AKI; sustained low efficiency dialysis; sled; pharmacokinetics; antimicrobials
MDPI and ACS Style

Brown, P.; Battistella, M. Principles of Drug Dosing in Sustained Low Efficiency Dialysis (SLED) and Review of Antimicrobial Dosing Literature. Pharmacy 2020, 8, 33.

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