Next Article in Journal
Genetic Diversity among Selected Medicago sativa Cultivars Using Inter-Retrotransposon-Amplified Polymorphism, Chloroplast DNA Barcodes and Morpho-Agronomic Trait Analyses
Next Article in Special Issue
Artemisia absinthium L.—Importance in the History of Medicine, the Latest Advances in Phytochemistry and Therapeutical, Cosmetological and Culinary Uses
Previous Article in Journal
Effects of Purple Seed Stain on Seed Quality and Composition in Soybean
Previous Article in Special Issue
Changes in the Content of Some Groups of Phenolic Compounds and Biological Activity of Extracts of Various Parts of Heather (Calluna vulgaris (L.) Hull) at Different Growth Stages
Open AccessArticle

Comparative and Functional Screening of Three Species Traditionally used as Antidepressants: Valeriana officinalis L., Valeriana jatamansi Jones ex Roxb. and Nardostachys jatamansi (D.Don) DC.

1
Department of Earth, Environment and Life Sciences, University of Genova, 16132 Genova, Italy
2
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy
3
ETT Spa, via Sestri 37, 16154 Genova, Italy
4
Institute of Biophysics-CNR, 16149 Genova, Italy
5
FEM2 Ambiente Srl, Piazza della Scienza 2, 20126 Milan, Italy
6
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
7
Nepal Herbs and Herbal Products Association, Kathmandu 44600, Nepal
8
European Herbal and Traditional Medicine Practitioners Association (EHTPA), Norwich 13815, UK
*
Author to whom correspondence should be addressed.
Plants 2020, 9(8), 994; https://doi.org/10.3390/plants9080994
Received: 6 July 2020 / Revised: 28 July 2020 / Accepted: 2 August 2020 / Published: 5 August 2020
(This article belongs to the Collection Bioactive Compounds in Plants)
The essential oils (EOs) of three Caprifoliaceae species, the Eurasiatic Valeriana officinalis (Vo), the Himalayan Valeriana jatamansi (Vj) and Nardostachys jatamansi (Nj), are traditionally used to treat neurological disorders. Roots/rhizomes micromorphology, DNA barcoding and EOs phytochemical characterization were carried out, while biological effects on the nervous system were assessed by acetylcholinesterase (AChE) inhibitory activity and microelectrode arrays (MEA). Nj showed the highest inhibitory activity on AChE (IC50 67.15 μg/mL) followed by Vo (IC50 127.30 μg/mL) and Vj (IC50 246.84 μg/mL). MEA analyses on rat cortical neurons, carried out by recording mean firing rate (MFR) and mean bursting rate (MBR), revealed stronger inhibition by Nj (IC50 18.8 and 11.1 μg/mL) and Vo (16.5 and 22.5 μg/mL), compared with Vj (68.5 and 89.3 μg/mL). These results could be related to different EO compositions, since sesquiterpenes and monoterpenes significantly contribute to the observed effects, but the presence of oxygenated compounds such as aldehydes and ketones is a discriminating factor in determining the order of potency. Our multidisciplinary approach represents an important tool to avoid the adulteration of herbal drugs and permits the evaluation of the effectiveness of EOs that could be used for a wide range of therapeutic applications. View Full-Text
Keywords: Caprifoliaceae; essential oil; acetylcholinesterase; neuroactive effects; MEA analyses; DNA barcoding; micromorphology; botanicals authentication Caprifoliaceae; essential oil; acetylcholinesterase; neuroactive effects; MEA analyses; DNA barcoding; micromorphology; botanicals authentication
Show Figures

Graphical abstract

MDPI and ACS Style

Cornara, L.; Ambu, G.; Trombetta, D.; Denaro, M.; Alloisio, S.; Frigerio, J.; Labra, M.; Ghimire, G.; Valussi, M.; Smeriglio, A. Comparative and Functional Screening of Three Species Traditionally used as Antidepressants: Valeriana officinalis L., Valeriana jatamansi Jones ex Roxb. and Nardostachys jatamansi (D.Don) DC.. Plants 2020, 9, 994.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop