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Volume 12
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10.3390/plants12020301
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Article

Rhanteriol, a New Rhanterium suaveolens Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes

by
Soumia Belaabed
1,
Ayoub Khalfaoui
1,
Valentina Parisi
2,3,
Valentina Santoro
2,
Daniela Russo
4,5,
Maria Ponticelli
4,*,
Magnus Monné
4,
Khellaf Rebbas
6,
Luigi Milella
4,* and
Giuliana Donadio
2
1
Department of Chemistry, Research Unit, Development of Natural Resources, Bioactive Molecules, Physicochemical and Biological Analysis, University Mentouri, Route Ain ElBey, Constantine 25000, Algeria
2
Dipartimento di Farmacia, Università Degli Studi di Salerno, via Giovanni Paolo II 132, Fisciano, 84084 Salerno, Italy
3
PhD Program in Drug Discovery and Development, Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano, 84084 Salerno, Italy
4
Dipartimento di Scienze, Università Degli Studi Della Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy
5
BioActiPlant s.r.l., Viale Dell’Ateneo Lucano 10, 85100 Potenza, Italy
6
Natural and Life Sciences Department, Mohamed Boudiaf University, M’Sila 28000, Algeria
*
Authors to whom correspondence should be addressed.
Plants 2023, 12(2), 301; https://doi.org/10.3390/plants12020301
Submission received: 25 November 2022 / Revised: 30 December 2022 / Accepted: 5 January 2023 / Published: 9 January 2023
(This article belongs to the Special Issue Natural Compounds–Successful Solutions for the Medical Challenges of the 21st Century - Part II)
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Abstract

Several specialized plant metabolites are reported to be enzyme inhibitors. In this investigation, the phytochemical composition and the biological activity of Rhanterium suaveolens Desf. were studied. One new lignan (rhanteriol 1) and seven known secondary metabolites were isolated from the aerial parts of R. suaveolens by using different chromatographic procedures. The biological properties of the R. suaveolens extracts and the new compound were evaluated by measuring their ability to inhibit the cholinesterase and carbohydrate-hydrolyzing enzymes, using cell-free in vitro methods. The new lignan, rhanteriol, was shown to inhibit α-amylase and α-glucosidase (IC50 = 46.42 ± 3.25 μM and 26.76 ± 3.29 μM, respectively), as well as butyrylcholinesterase (IC50 = 10.41 ± 0.03 μM), with an effect comparable to that of the respective standards, acarbose and galantamine. Furthermore, docking studies were performed suggesting the interaction mode of rhanteriol with the active sites of the investigated enzymes. The obtained data demonstrated that the aerial part of R. suaveolens could represent a source of active molecules, such as rhanteriol, usable in the development of treatments for preventing or treating type 2 diabetes mellitus and neurodegeneration.
Keywords: Rhanterium suaveolens Desf.; rhanteriol 1; NMR; α-amylase inhibition; α-glucosidase inhibition; cholinesterases inhibition; molecular docking Rhanterium suaveolens Desf.; rhanteriol 1; NMR; α-amylase inhibition; α-glucosidase inhibition; cholinesterases inhibition; molecular docking

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MDPI and ACS Style

Belaabed, S.; Khalfaoui, A.; Parisi, V.; Santoro, V.; Russo, D.; Ponticelli, M.; Monné, M.; Rebbas, K.; Milella, L.; Donadio, G. Rhanteriol, a New Rhanterium suaveolens Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes. Plants 2023, 12, 301. https://doi.org/10.3390/plants12020301

AMA Style

Belaabed S, Khalfaoui A, Parisi V, Santoro V, Russo D, Ponticelli M, Monné M, Rebbas K, Milella L, Donadio G. Rhanteriol, a New Rhanterium suaveolens Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes. Plants. 2023; 12(2):301. https://doi.org/10.3390/plants12020301

Chicago/Turabian Style

Belaabed, Soumia, Ayoub Khalfaoui, Valentina Parisi, Valentina Santoro, Daniela Russo, Maria Ponticelli, Magnus Monné, Khellaf Rebbas, Luigi Milella, and Giuliana Donadio. 2023. "Rhanteriol, a New Rhanterium suaveolens Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes" Plants 12, no. 2: 301. https://doi.org/10.3390/plants12020301

APA Style

Belaabed, S., Khalfaoui, A., Parisi, V., Santoro, V., Russo, D., Ponticelli, M., Monné, M., Rebbas, K., Milella, L., & Donadio, G. (2023). Rhanteriol, a New Rhanterium suaveolens Desf. Lignan with Pharmacological Potential as an Inhibitor of Enzymes Involved in Neurodegeneration and Type 2 Diabetes. Plants, 12(2), 301. https://doi.org/10.3390/plants12020301

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