Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development
Round 1
Reviewer 1 Report
The review entitled Enhanced Extraction Performance of Phytochemical Constituents by NaDES for
Pharmaceutical Application Purposes: A Narrative Review is focused on the application of NaDes in the
optimization of phytochemicals from natural sources. The manuscript has not great novelty, as many
reviews have been published in recent years on this topic: 1) Zainal-Abidin et al. "New horizons in the
extraction of bioactive compounds using deep eutectic solvents: A review." Analytica chimica acta 979
(2017): 1-23; 2); 2) Ivanović et al. "Innovative Extraction techniques using deep eutectic solvents and
analytical methods for the isolation and characterization of natural bioactive compounds from plant
material." Plants 9.11 (2020): 1428. However, due to the current great attention to Green, this narrative
review should be suitable for publication after major revisions, as suggested below.
An extensive English editing is required: please, remove unformal words, like ‘and so on’; remove ‘the’ in
sources of medicinal ingredients (line 34); revise verb choice (should is more appropriate than must at line
35), add fluency and readability to the manuscript by removing some bulleted lists and simplifying
sentences (e.g. lines 42-46; lines 46-48 ‘The limitations of conventional organic solvents as extraction solvents
trigger efforts to replace these solvents in the extraction process, one of which is by using green solvents’ should be
simplify in ‘the use of green solvent could overcome the limitations of conventional organic solvents);line 52-53 is
grammatically incorrect, you should simplify in ‘among them, Natural Deep Eutectic Solvents (NaDES) have
received great attention from researchers’. A general rephrasing is highly recommended.
When you cite a normal solvent, you should write n in italic font.
When you cite a botanic specie, you must write the botanical classifier (for example, Curcuma longa L.).
Author Response
Dear Reviewer,
We have made improvements to the script.
Please see the attachment.
Regards,
Authors
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript is well organized and well written and takes into consideration different aspects of the topic. In my opinion, it is suitable for publication after minor revision, as follows:
- The title could be slightly modified, as plant extracts and their constituents obtained by NaDES could be used also in nutraceutical field. I suggest to add this information
- Future perspective sub-section: the first part (lines 479-501) is not a future perspective. I suggest to shift this part before and build a paragraph "Conclusion and future perspective).
Author Response
Dear Reviewer,
We have made improvements to the script.
Please see the attachment.
Regards,
Authors
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Authors addressed all requested modification.
best regards
lm
