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Article

Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats

1
Chung-Yeon Central Institute, 64, Sangmujungang-ro, Seo-gu, Gwangju 61949, Korea
2
Imsil County Health and Medical Center, Imsil 55927, Korea
3
Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam 13120, Korea
*
Authors to whom correspondence should be addressed.
Plants 2021, 10(1), 42; https://doi.org/10.3390/plants10010042
Received: 19 November 2020 / Revised: 15 December 2020 / Accepted: 16 December 2020 / Published: 26 December 2020
Osteoarthritis (OA) is an age-related joint disease and one of the most common degenerative bone diseases among elderly people. The currently used therapeutic strategies relying on nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids for OA are often associated with gastrointestinal, cardiovascular, and kidney disorders, despite being proven effective. Aucklandia lappa is a well-known traditional medicine. The root of A. lappa root has several bioactive compounds and has been in use as a natural remedy for bone diseases and other health conditions. We evaluated the A. lappa root extracts on OA progression as a natural therapeutic agent. A. lappa substantially reduced writhing numbers in mice induced with acetic acid. Monosodium iodoacetate (MIA) was injected into the rats through their knee joints of rats to induce experimental OA, which shows similar pathological characteristics to OA in human. A. lappa substantially reduced the MIA-induced weight-bearing of hind limb and reversed the cartilage erosion in MIA rats. IL-1β, a representative inflammatory mediator in OA, was also markedly decreased by A. lappa in the serum of MIA rats. In vitro, A. lappa lowered the secretion of NO and suppressed the IL-1β, COX-2, IL-6, and iNOS production in RAW264.7 macrophages activated with LPS. Based on its analgesic and anti-inflammatory effects, A. lappa could be a potential remedial agent against OA. View Full-Text
Keywords: osteoarthritis; Aucklandia lappa; analgesic; anti-inflammatory; MIA rats osteoarthritis; Aucklandia lappa; analgesic; anti-inflammatory; MIA rats
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MDPI and ACS Style

Jo, H.-G.; Lee, G.-Y.; Baek, C.Y.; Song, H.S.; Lee, D. Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Plants 2021, 10, 42. https://doi.org/10.3390/plants10010042

AMA Style

Jo H-G, Lee G-Y, Baek CY, Song HS, Lee D. Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Plants. 2021; 10(1):42. https://doi.org/10.3390/plants10010042

Chicago/Turabian Style

Jo, Hee-Geun, Geon-Yeong Lee, Chae Y. Baek, Ho S. Song, and Donghun Lee. 2021. "Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats" Plants 10, no. 1: 42. https://doi.org/10.3390/plants10010042

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