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Volume 10
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10.3390/plants10010171
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Article

Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage

by
SeonJu Park
1,†,
Seo Yule Jeong
2,†,
Youn Hee Nam
2,
Jun Hyung Park
3,
Isabel Rodriguez
2,
Ji Heon Shim
2,
Tamanna Yasmin
2,
Hee Jae Kwak
3,
Youngse Oh
3,
Mira Oh
3,
Kye Wan Lee
4,
Jung Suk Lee
4,
Do Hoon Kim
4,
Yu Hwa Park
4,
In Seok Moon
5,
Se-Young Choung
6,
Kwang Won Jeong
7,
Bin Na Hong
2,
Seung Hyun Kim
3,* and
Tong Ho Kang
2,*
1
Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea
2
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
3
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
4
R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea
5
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
6
Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul 02453, Korea
7
Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea
*
Authors to whom correspondence should be addressed.
†
These two authors contributed equally to the work.
Plants 2021, 10(1), 171; https://doi.org/10.3390/plants10010171
Submission received: 8 December 2020 / Revised: 4 January 2021 / Accepted: 10 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Isolation and Analysis of Characteristic Compounds from Herbal and Plant Extracts)
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Abstract

Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.
Keywords: avocado oil; fatty acids; hearing loss; zebrafish; hair cell avocado oil; fatty acids; hearing loss; zebrafish; hair cell

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MDPI and ACS Style

Park, S.; Jeong, S.Y.; Nam, Y.H.; Park, J.H.; Rodriguez, I.; Shim, J.H.; Yasmin, T.; Kwak, H.J.; Oh, Y.; Oh, M.; et al. Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage. Plants 2021, 10, 171. https://doi.org/10.3390/plants10010171

AMA Style

Park S, Jeong SY, Nam YH, Park JH, Rodriguez I, Shim JH, Yasmin T, Kwak HJ, Oh Y, Oh M, et al. Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage. Plants. 2021; 10(1):171. https://doi.org/10.3390/plants10010171

Chicago/Turabian Style

Park, SeonJu, Seo Yule Jeong, Youn Hee Nam, Jun Hyung Park, Isabel Rodriguez, Ji Heon Shim, Tamanna Yasmin, Hee Jae Kwak, Youngse Oh, Mira Oh, and et al. 2021. "Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage" Plants 10, no. 1: 171. https://doi.org/10.3390/plants10010171

APA Style

Park, S., Jeong, S. Y., Nam, Y. H., Park, J. H., Rodriguez, I., Shim, J. H., Yasmin, T., Kwak, H. J., Oh, Y., Oh, M., Lee, K. W., Lee, J. S., Kim, D. H., Park, Y. H., Moon, I. S., Choung, S.-Y., Jeong, K. W., Hong, B. N., Kim, S. H., & Kang, T. H. (2021). Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage. Plants, 10(1), 171. https://doi.org/10.3390/plants10010171

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