SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients

Hussein, Usama Khamis; Ahmed, Asmaa Gamal; Choi, Won Ku; Kim, Kyoung Min; Park, See-Hyoung; Park, Ho Sung; Noh, Sang Jae; Lee, Ho; Chung, Myoung Ja; Moon, Woo Sung; Kang, Myoung Jae; Cho, Dong Hyu; Jang, Kyu Yun

doi:10.3390/biom11030405

Open AccessArticle

SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients

by

Usama Khamis Hussein

^1,2,3,†,

Asmaa Gamal Ahmed

^1,4,†,

Won Ku Choi

^2,5,†,

Kyoung Min Kim

^1,2,

See-Hyoung Park

⁶

,

Ho Sung Park

^1,2

,

Sang Jae Noh

⁷

,

Ho Lee

⁷,

Myoung Ja Chung

^1,2,

Woo Sung Moon

^1,2,

Myoung Jae Kang

^1,2,

Dong Hyu Cho

^2,5,* and

Kyu Yun Jang

^1,2,*

¹

Department of Pathology, Jeonbuk National University Medical School, Jeonju 54896, Korea

²

Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea

³

Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt

⁴

Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt

⁵

Department of Obstetrics and Gynecology, Jeonbuk National University Medical School, Jeonju 54896, Korea

⁶

Department of Bio and Chemical Engineering, Hongik University, Sejong 30016, Korea

⁷

Department of Forensic Medicine, Jeonbuk National University Medical School, Jeonju 54896, Korea

^*

Authors to whom correspondence should be addressed.

^†

Contributed equally to the study.

Biomolecules 2021, 11(3), 405; https://doi.org/10.3390/biom11030405

Submission received: 11 January 2021 / Revised: 5 March 2021 / Accepted: 6 March 2021 / Published: 9 March 2021

(This article belongs to the Special Issue EMT and Cancer)

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Abstract

SCRIB is a polarity protein important in maintaining cell junctions. However, recent reports have raised the possibility that SCRIB might have a role in human cancers. Thus, this study evaluated the roles of SCRIB in ovarian cancers. In 102 human ovarian carcinomas, nuclear expression of SCRIB predicted shorter survival of ovarian carcinoma patients, especially in the patients who received post-operative chemotherapy. In SKOV3 and SNU119 ovarian cancer cells, overexpression of SCRIB stimulated the proliferation and invasion of cells. Knockout of SCRIB inhibited in vivo tumor growth of SKOV3 cells and overexpression of SCRIB promoted tumor growth. Overexpression of SCRIB stimulated epithelial-to-mesenchymal transition by increasing the expression of N-cadherin, snail, TGF-β1, and smad2/3, and decreasing the expression of E-cadherin; the converse was observed with inhibition of SCRIB. In conclusion, this study presents the nuclear expression of SCRIB as a prognostic marker of ovarian carcinomas and suggests that SCRIB is involved in the progression of ovarian carcinomas by stimulating proliferation and epithelial-to-mesenchymal transition-related invasiveness.

Keywords: ovary; cancer; SCRIB; epithelial-to-mesenchymal transition; prognosis

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MDPI and ACS Style

Hussein, U.K.; Ahmed, A.G.; Choi, W.K.; Kim, K.M.; Park, S.-H.; Park, H.S.; Noh, S.J.; Lee, H.; Chung, M.J.; Moon, W.S.; et al. SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients. Biomolecules 2021, 11, 405. https://doi.org/10.3390/biom11030405

AMA Style

Hussein UK, Ahmed AG, Choi WK, Kim KM, Park S-H, Park HS, Noh SJ, Lee H, Chung MJ, Moon WS, et al. SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients. Biomolecules. 2021; 11(3):405. https://doi.org/10.3390/biom11030405

Chicago/Turabian Style

Hussein, Usama Khamis, Asmaa Gamal Ahmed, Won Ku Choi, Kyoung Min Kim, See-Hyoung Park, Ho Sung Park, Sang Jae Noh, Ho Lee, Myoung Ja Chung, Woo Sung Moon, and et al. 2021. "SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients" Biomolecules 11, no. 3: 405. https://doi.org/10.3390/biom11030405

APA Style

Hussein, U. K., Ahmed, A. G., Choi, W. K., Kim, K. M., Park, S.-H., Park, H. S., Noh, S. J., Lee, H., Chung, M. J., Moon, W. S., Kang, M. J., Cho, D. H., & Jang, K. Y. (2021). SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients. Biomolecules, 11(3), 405. https://doi.org/10.3390/biom11030405

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SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients

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