Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine
Abstract
:1. Introduction
2. Structure and Physico-Chemical Properties
3. Chitosan in Tissue Engineering and Regenerative Medicine
3.1. Chitosan for Wound Healing
3.2. Bone and Cartilage Regeneration
3.2.1. Bone
3.2.2. Cartilage
3.3. Chitosan for Drug Delivery
4. Conclusions
Funding
Conflicts of Interest
References
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CS/Derivatives | Type/Delivery System | Application | Ref. |
---|---|---|---|
N-succinyl-N′-octyl chitosan (SOC) | Self-assembled polymeric micelles | Controlled anticancer drug release | [108,137] |
Tumor targeted therapy | [138,139,140] | ||
Biomedical optical imaging | [141] | ||
N-octyl-N-trimethyl chitosan | Self-assembled polymeric micelles | Controlled anticancer drug release | [142] |
Tumor targeted therapy | [143] | ||
N-octyl-O-sulfate chitosan | Self-assembled polymeric micelles | Absorption enhancement of anticancer drug | [144,145] |
Tumor targeted therapy | [146,147,148] | ||
Increasing stability of drug loaded liposomes | [149] | ||
2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan | Powder | Pharmaceutical and food industries | [150] |
(Ser-Ile-Lys-Val-Ala-Val) peptide-modified chitosan | Hydrogel | Skin substitutes for wound closure in mice | [53,151] |
Galactosylated chitosan (GC) | NPs | Tumor targeted therapy | [152,153,154,155] |
siRNA delivery | [156,157] | ||
N-palmitoyl chitosan (NPCS) | MPs and micelles | Tumor targeted therapy | [158,159] |
O-palmitoyl chitosan (OPC) | Liposomes | Intestinal drug delivery | [160] |
Hydroxyapatite/CS | NPs | Drug delivery | [161,162,163,164] |
CS loaded with antioxidant NPs | Hydrogel | Drug release | [165] |
PEGylated CS | NPs | Tumor targeted therapy | [166,167,168] |
Chitosan-based vaccine | Polyelectrolyte, NPs | Intranasal CS-DNA vaccine | [169,170] |
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Sultankulov, B.; Berillo, D.; Sultankulova, K.; Tokay, T.; Saparov, A. Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine. Biomolecules 2019, 9, 470. https://doi.org/10.3390/biom9090470
Sultankulov B, Berillo D, Sultankulova K, Tokay T, Saparov A. Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine. Biomolecules. 2019; 9(9):470. https://doi.org/10.3390/biom9090470
Chicago/Turabian StyleSultankulov, Bolat, Dmitriy Berillo, Karina Sultankulova, Tursonjan Tokay, and Arman Saparov. 2019. "Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine" Biomolecules 9, no. 9: 470. https://doi.org/10.3390/biom9090470