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Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity

Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, RN, Brazil
Production and Drug Control Department, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil
Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Manaus 69077-000, AM, Brazil
Graduate Program of Biotechnology, Laureate International Universities (UnP), Natal 59056-000, RN, Brazil
Chemical Engineering Department, Military Institute of Engineering, Rio de Janeiro 22290-270, RJ, Brazil
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(6), 241;
Received: 3 May 2019 / Revised: 15 June 2019 / Accepted: 16 June 2019 / Published: 21 June 2019
(This article belongs to the Special Issue Evaluation and formulation of Bioactive Terpenes)
α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD’s as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM. View Full-Text
Keywords: amyrin; cyclodextrin; inclusion complexes; anti-inflammatory amyrin; cyclodextrin; inclusion complexes; anti-inflammatory
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da Silva Júnior, W.F.; Bezerra de Menezes, D.L.; de Oliveira, L.C.; Koester, L.S.; Oliveira de Almeida, P.D.; Lima, E.S.; de Azevedo, E.P.; da Veiga Júnior, V.F.; Neves de Lima, Á.A. Inclusion Complexes of β and HPβ-Cyclodextrin with α, β Amyrin and In Vitro Anti-Inflammatory Activity. Biomolecules 2019, 9, 241.

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