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Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation

Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Biology Institute, University of Campinas, UNICAMP, Rua Monteiro Lobato, 255, Campinas, São Paulo 13083862, Brazil
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Biomolecules 2019, 9(6), 229; https://doi.org/10.3390/biom9060229
Received: 16 May 2019 / Revised: 5 June 2019 / Accepted: 8 June 2019 / Published: 13 June 2019
Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved muscle protein turnover by modifying the mTOR and proteolytic pathways, thus we analysed whether maternal supplementation could ameliorate muscle protein turnover in adult offspring tumour-bearing rats. Pregnant Wistar rats received a control diet or 3% leucine-rich diet during pregnancy/lactation, and their weaned male offspring received a control diet until adulthood when they were distributed into following groups (n = 7–8 per group): C, Control; W, tumour-bearing; L, without tumour with a maternal leucine-rich diet; and WL, tumour-bearing with a maternal leucine-rich diet. Protein synthesis and degradation were assessed in the gastrocnemius muscle, focusing on the mTOR pathway, which was extensively altered in W group. However, the WL adult offspring showed no decrease in muscle weight, higher food intake, ameliorated muscle turnover, activated mTOR and p70S6K, and maintained muscle cathepsin H and calpain activities. Maternal leucine nutritional supplementation could be a positive strategy to improve muscle protein balance in cancer cachexia-induced muscle damage in adult offspring rats. View Full-Text
Keywords: branched-chain amino acid; cancer cachexia; maternal influence; muscle protein turnover branched-chain amino acid; cancer cachexia; maternal influence; muscle protein turnover
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MDPI and ACS Style

Miyaguti, N.A.d.S.; Oliveira, S.C.P.d.; Gomes-Marcondes, M.C.C. Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation. Biomolecules 2019, 9, 229. https://doi.org/10.3390/biom9060229

AMA Style

Miyaguti NAdS, Oliveira SCPd, Gomes-Marcondes MCC. Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation. Biomolecules. 2019; 9(6):229. https://doi.org/10.3390/biom9060229

Chicago/Turabian Style

Miyaguti, Natália A.d.S.; Oliveira, Sarah C.P.d.; Gomes-Marcondes, Maria C.C. 2019. "Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation" Biomolecules 9, no. 6: 229. https://doi.org/10.3390/biom9060229

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