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Biomolecules 2019, 9(3), 97; https://doi.org/10.3390/biom9030097

The Relationship between Epicardial Adipose Tissue Thickness and Serum Interleukin-17a Level in Patients with Isolated Metabolic Syndrome

1
Department of İnternal Medicine, Kanuni Sultan Süleyman Education and Research Hospital, 34103 İstanbul, Turkey
2
Department of İnternal Medicine, Bakırköy Dr Sadi Konuk Education and Research Hospital, 34147 İstanbul, Turkey
3
Department of Cardiology, Medeniyet University Medical Faculty, 34722 İstanbul, Turkey
4
Department of Cardiology, Konya Education and Research Hospital, 42040 Konya, Turkey
5
Department of Cardiology, Bakırköy Dr Sadi Konuk Education and Research Hospital, 34147 İstanbul, Turkey
*
Author to whom correspondence should be addressed.
Received: 6 February 2019 / Revised: 26 February 2019 / Accepted: 5 March 2019 / Published: 11 March 2019
(This article belongs to the Special Issue Obesity and Hormones)
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Abstract

In this study, it was aimed to investigate the relationship between the epicardial adipose tissue thickness (EATT) and serum IL-17A level insulin resistance in metabolic syndrome patients. This study enrolled a total of 160 subjects, of whom 80 were consecutive patients who applied to our outpatient clinic and were diagnosed with metabolic syndrome, and the other 80 were consecutive patients who were part of the control group with similar age and demographics in whom the metabolic syndrome was excluded. The metabolic syndrome diagnosis was made according to International Diabetes Federation (IDF)-2005 criteria. EATT was measured with transthoracic echocardiography (TTE) in the subjects. IL-17A serum levels were determined using the ELISA method. Fasting blood glucose, HDL, triglyceride, and fasting insulin levels were significantly higher in the metabolic syndrome group compared to the control group. In addition, the metabolic syndrome group had significantly higher high-sensitivity C-reactive protein (hs-CRP) and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) levels than the control group. Similarly, serum IL-17A levels were significantly elevated in the metabolic syndrome group compared to the control group statistically (p < 0.001). As well, EATT was higher in the metabolic syndrome than the control group. Conclusion: By virtue of their proinflammatory properties, EATT and IL-17 may play an important role in the pathogenesis of the metabolic syndrome. View Full-Text
Keywords: metabolic syndrome; adipose tissue; interleukin 17A metabolic syndrome; adipose tissue; interleukin 17A
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Demir, E.; Harmankaya, N.Ö.; Kıraç Utku, İ.; Açıksarı, G.; Uygun, T.; Özkan, H.; Demir, B. The Relationship between Epicardial Adipose Tissue Thickness and Serum Interleukin-17a Level in Patients with Isolated Metabolic Syndrome. Biomolecules 2019, 9, 97.

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