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Biomolecules 2019, 9(3), 96; https://doi.org/10.3390/biom9030096

The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus

1
Department of Internal Medicine, Istanbul Training and Research Hospital, Fatih, Istanbul, 34098, Turkey
2
Department of Biochemistry, Yildiz Technical University, Esenler, Istanbul, 34220, Turkey
3
Department of Ophthalmology, Istanbul Training and Research Hospital, Fatih, Istanbul, 34098, Turkey
4
Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Fatih, Istanbul, 34098, Turkey
*
Author to whom correspondence should be addressed.
Received: 26 December 2018 / Revised: 5 March 2019 / Accepted: 7 March 2019 / Published: 11 March 2019
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Abstract

Background: Taurine has an active role in providing glucose homeostasis and diabetes causes a decline in taurine levels. This paper investigates the relationship between taurine and diabetic complications, patients’ demographic features, and biochemical parameters. Methods: Fifty-nine patients with type 2 diabetes mellitus (T2DM), and 28 healthy control subjects between the ages of 32 and 82 were included in the study. The mean age of subjects was 55.6 ± 10.3 and mean diabetes duration was 10.2 ± 6.0 years. The most commonly accompanying comorbidity was hypertension (HT) (64.5%, n = 38), and the most frequent diabetic complication was neuropathy (50.8%, n = 30). Plasma taurine concentrations were measured by an enzyme-linked immunoassay (ELISA) kit. Results: Plasma taurine concentrations were significantly lower in diabetic patients (0.6 ± 0.1 mmol/L) than controls (0.8 ± 0.2 mmol/L) and in hypertensive (0. 6 ± 0.1 mmol/L) patients (p = 0.000, p = 0.027 respectively). Conclusion: Plasma taurine levels were decreased in patients with T2DM and this was not related to FBG, HbA1c, and microalbuminuria. With regard to complications, we only found a correlation with neuropathy. We suggest that taurine levels may be more important in the development of diabetes; however, it may also have importance for the progression of the disease and the subsequent complications. We further assert that taurine measurement at different times may highlight whether there is a causal relationship in the development of complications. View Full-Text
Keywords: diabetes; taurine; diabetic retinopathy; diabetic neuropathy; microalbuminuria diabetes; taurine; diabetic retinopathy; diabetic neuropathy; microalbuminuria
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Sak, D.; Erdenen, F.; Müderrisoglu, C.; Altunoglu, E.; Sozer, V.; Gungel, H.; Guler, P.A.; Sak, T.; Uzun, H. The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus. Biomolecules 2019, 9, 96.

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