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Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K

Department of Structural and Computational Biology, University of Vienna, Max F. Perutz Laboratories Vienna BioCenter, Campus Vienna Biocenter 5, Rm. 1.624, 1030 Vienna, Austria
Biomolecules 2019, 9(2), 67;
Received: 11 January 2019 / Revised: 11 February 2019 / Accepted: 12 February 2019 / Published: 16 February 2019
(This article belongs to the Special Issue Phosphoinositide 3-kinase, a Field in Transition)
PDF [1730 KB, uploaded 16 February 2019]


Intracellular signaling pathways mediate the rapid response of cells to environmental cues. To control the fidelity of these responses, cells coordinate the activities of signaling enzymes with the strength, timing, and localization of the upstream stimuli. Protein kinase Akt links the PI3K-coupled receptors to cellular anabolic processes by phosphorylating multiple substrates. How the cells ensure that Akt activity remains proportional to upstream signals and control its substrate specificity is unclear. In this review, I examine how cell-autonomous and intrinsic allosteric mechanisms cooperate to ensure localized, context-specific signaling in the PI3K/Akt axis. View Full-Text
Keywords: PI3K; protein kinase Akt; cellular signaling PI3K; protein kinase Akt; cellular signaling

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Yudushkin, I. Getting the Akt Together: Guiding Intracellular Akt Activity by PI3K. Biomolecules 2019, 9, 67.

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