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Review

New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures

Developmental Biology, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2019, 9(12), 860; https://doi.org/10.3390/biom9120860
Received: 21 October 2019 / Revised: 6 December 2019 / Accepted: 9 December 2019 / Published: 11 December 2019
(This article belongs to the Special Issue Retinoids in Embryonic Development)
Retinoic acid (RA) signaling is an important regulator of chordate development. RA binds to nuclear RA receptors that control the transcriptional activity of target genes. Controlled local degradation of RA by enzymes of the Cyp26a gene family contributes to the establishment of transient RA signaling gradients that control patterning, cell fate decisions and differentiation. Several steps in the lineage leading to the induction and differentiation of neuromesodermal progenitors and bone-producing osteogenic cells are controlled by RA. Changes to RA signaling activity have effects on the formation of the bones of the skull, the vertebrae and the development of teeth and regeneration of fin rays in fish. This review focuses on recent advances in these areas, with predominant emphasis on zebrafish, and highlights previously unknown roles for RA signaling in developmental processes. View Full-Text
Keywords: retinoic acid; spinal cord; neuromesodermal precursors; notochord; vertebrae; calvaria; osteoblasts; teeth; dentition; regeneration retinoic acid; spinal cord; neuromesodermal precursors; notochord; vertebrae; calvaria; osteoblasts; teeth; dentition; regeneration
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MDPI and ACS Style

Draut, H.; Liebenstein, T.; Begemann, G. New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures. Biomolecules 2019, 9, 860. https://doi.org/10.3390/biom9120860

AMA Style

Draut H, Liebenstein T, Begemann G. New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures. Biomolecules. 2019; 9(12):860. https://doi.org/10.3390/biom9120860

Chicago/Turabian Style

Draut, Heidrun, Thomas Liebenstein, and Gerrit Begemann. 2019. "New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures" Biomolecules 9, no. 12: 860. https://doi.org/10.3390/biom9120860

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