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In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
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Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease

1
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
2
Departments of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
3
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
*
Authors to whom correspondence should be addressed.
Biomolecules 2019, 9(12), 817; https://doi.org/10.3390/biom9120817
Received: 8 September 2019 / Revised: 11 November 2019 / Accepted: 15 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Advances in Cholinesterases)
Spanning three decades in research, Paraoxonases (PON1) carried potential of dealing with neurotoxicity of organophosphates entering the circulation and preventing cholinergic crisis. In the past few years, the Paraoxonase multigene family (PON1, PON2, PON3) has been shown to play an important role in pathogenesis of cardiovascular disorders including coronary artery disease (CAD). The PON genes are clustered in tandem on the long arm of human chromosome 7 (q21, 22). All of them have been shown to act as antioxidants. Of them, PON3 is the least studied member as its exact physiological substrate is still not clear. This has further led to limitation in our understanding of its role in pathogenesis of CAD and development of the potential therapeutic agents which might modulate its activity, expression in circulation and tissues. In the present review, we discuss the structure and activity of human PON3 enzyme and its Single nucleotide variants that could potentially lead to new clinical strategies in prevention and treatment of CAD. View Full-Text
Keywords: Paraoxonase 3; polymorphisms; PON3 activity; statinase; coronary artery disease; HDL Paraoxonase 3; polymorphisms; PON3 activity; statinase; coronary artery disease; HDL
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Priyanka, K.; Singh, S.; Gill, K. Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease. Biomolecules 2019, 9, 817.

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