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Open AccessArticle

Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia

1
Institute of Internal and Preventive Medicine – branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 630089 Novosibirsk, Russia
2
Federal research center Institute of Cytology and Genetics, SB RAS, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(11), 739; https://doi.org/10.3390/biom9110739
Received: 11 October 2019 / Revised: 7 November 2019 / Accepted: 12 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Bioactive Lipids in Health and Disease)
The TaqI B (rs708272) single-nucleotide variant, i.e., the +279 G/A substitution in intron 1 of the CETP gene, is actively investigated as a risk factor of lipid metabolism disorders. The aim of this study was to analyze the association of rs708272 with lipid parameters and the risk of myocardial infarction in the population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 participants, >90% white, aged 45–69 years, males: 50%). In total, 3132 randomly selected patients were included. Plasma lipid levels were determined by standard enzymatic assays. Rs708272 was analyzed by RT-PCR via TaqMan single-nucleotide polymorphism (SNP) Genotyping Assays (Thermo Fisher Scientific, USA). The frequencies of rs708272 genotypes AA (homozygote), AG (heterozygote), and GG were 0.21, 0.49, and 0.30, respectively, in this population. Allele A frequency was 0.46. We found an association of allele G with low levels of high-density lipoprotein cholesterol and a high index of atherogenicity in this population (p < 0.001 and p < 0.001, respectively). Allele G was significantly associated with the risk of myocardial infarction among the male participants (odds ratio 1.96, 95% confidence interval 1.208–3.178, p = 0.008) and in the study population (odds ratio 1.465, 95% confidence interval 1.028–2.087, p = 0.036). Thus, rs708272 is associated with myocardial infarction in the white population of Western Siberia (Russia). View Full-Text
Keywords: rs708272; risk of cardiovascular disease; lipid profile; white population; Western Siberia rs708272; risk of cardiovascular disease; lipid profile; white population; Western Siberia
MDPI and ACS Style

Semaev, S.; Shakhtshneider, E.; Orlov, P.; Ivanoshchuk, D.; Malyutina, S.; Gafarov, V.; Ragino, Y.; Voevoda, M. Association of RS708272 (CETP Gene Variant) with Lipid Profile Parameters and the Risk of Myocardial Infarction in the White Population of Western Siberia. Biomolecules 2019, 9, 739.

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