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The Roles of Notch Signaling in Liver Development and Disease
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Notch Signaling in Kidney Development, Maintenance, and Disease

1
Pediatrics and Rare Diseases Group, Sanford Research, 2301 East 60th Street North, Sioux Falls, SD 57104, USA
2
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA
3
Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(11), 692; https://doi.org/10.3390/biom9110692
Received: 28 September 2019 / Revised: 31 October 2019 / Accepted: 2 November 2019 / Published: 4 November 2019
Kidney development involves formation of nephrons intricately aligned with the vasculature and connected to a branched network of collecting ducts. Notch signaling plays multiple roles during kidney development involving the formation of nephrons composed of diverse epithelial cell types arranged into tubular segments, all the while maintaining a nephron progenitor niche. Here, we review the roles of Notch signaling identified from rodent kidney development and injury studies, while discussing human kidney diseases associated with aberrant Notch signaling. We also review Notch signaling requirement in maintenance of mature kidney epithelial cell states and speculate that Notch activity regulation mediates certain renal physiologic adaptations. View Full-Text
Keywords: Alagille syndrome; Notch; congenital anomalies of the kidney; nephrogenesis; cell fate selection Alagille syndrome; Notch; congenital anomalies of the kidney; nephrogenesis; cell fate selection
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Mukherjee, M.; Fogarty, E.; Janga, M.; Surendran, K. Notch Signaling in Kidney Development, Maintenance, and Disease. Biomolecules 2019, 9, 692.

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