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Open AccessArticle

Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome

1
Nutrition-Gut-Brain Interactions Research Centre, Faculty of Health and Medicine, School of Medical Sciences, Örebro University, 701 82 Örebro, Sweden
2
Nutrition, Metabolism and Genomics group, Division of Human Nutrition and Health, Wageningen University, 6708 PB Wageningen, The Netherlands
3
Laboratory of Microbiology, Wageningen University and Research Centre, 6708 PB Wageningen, The Netherlands
4
Human Microbiome Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(10), 586; https://doi.org/10.3390/biom9100586
Received: 31 July 2019 / Revised: 3 October 2019 / Accepted: 4 October 2019 / Published: 8 October 2019
(This article belongs to the Special Issue Role of the Gut Microbiota in Immunity and Inflammatory Diseases)
Faecal microbiota transfer (FMT) consists of the introduction of new microbial communities into the intestine of a patient, with the aim of restoring a disturbed gut microbiota. Even though it is used as a potential treatment for various diseases, it is unknown how the host mucosa responds to FMT. This study aims to investigate the colonic mucosa gene expression response to allogenic (from a donor) or autologous (own) FMT in patients with irritable bowel syndrome (IBS). In a recently conducted randomised, double-blinded, controlled clinical study, 17 IBS patients were treated with FMT by colonoscopy. RNA was isolated from colonic biopsies collected by sigmoidoscopy at baseline, as well as two weeks and eight weeks after FMT. In patients treated with allogenic FMT, predominantly immune response-related gene sets were induced, with the strongest response two weeks after the FMT. In patients treated with autologous FMT, predominantly metabolism-related gene sets were affected. Furthermore, several microbiota genera showed correlations with immune-related gene sets, with different correlations found after allogenic compared to autologous FMT. This study shows that the microbe–host response is influenced by FMT on the mucosal gene expression level, and that there are clear differences in response to allogenic compared to autologous FMT. View Full-Text
Keywords: faecal microbiota transplantation; irritable bowel syndrome; gene expression; microbiota; host-microbe interaction faecal microbiota transplantation; irritable bowel syndrome; gene expression; microbiota; host-microbe interaction
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Holster, S.; Hooiveld, G.J.; Repsilber, D.; de Vos, W.M.; Brummer, R.J.; König, J. Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome. Biomolecules 2019, 9, 586.

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