Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Study Design and Sampling
4.2. Islet-Cell Autoimmunity Determination
4.3. Sample Preparation and Ultra High Performance Liquid Chromatography-Mass Spectrometer Analysis
4.4. Data Pre-Processing
4.5. Statistical Analysis
Supplementary Materials
Author Contributions
Acknowledgments
Conflicts of Interest
References
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PT1D (n = 30) | P1Ab (n = 33) | CTR (n = 38) | |
---|---|---|---|
Gender (girls, boys) | (12, 18) | (12, 21) | (14, 24) |
Age at time of diagnosis (years) (mean ± SE) | 4.94 ± 0.56 | NA | NA |
Age at time of first seroconversion (years) (mean ± SE) | 1.28 ± 0.11 | 3.03 ± 0.45 | NA |
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Lamichhane, S.; Ahonen, L.; Sparholt Dyrlund, T.; Dickens, A.M.; Siljander, H.; Hyöty, H.; Ilonen, J.; Toppari, J.; Veijola, R.; Hyötyläinen, T.; et al. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules 2019, 9, 33. https://doi.org/10.3390/biom9010033
Lamichhane S, Ahonen L, Sparholt Dyrlund T, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, et al. Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules. 2019; 9(1):33. https://doi.org/10.3390/biom9010033
Chicago/Turabian StyleLamichhane, Santosh, Linda Ahonen, Thomas Sparholt Dyrlund, Alex M. Dickens, Heli Siljander, Heikki Hyöty, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Tuulia Hyötyläinen, and et al. 2019. "Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes" Biomolecules 9, no. 1: 33. https://doi.org/10.3390/biom9010033