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Biomolecules 2018, 8(3), 66;

Potential Impact of Oral Inflammations on Cardiac Functions and Atrial Fibrillation

Department of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20251 Hamburg, Germany
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20251 Hamburg, Germany
Author to whom correspondence should be addressed.
Received: 21 June 2018 / Revised: 14 July 2018 / Accepted: 26 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Biomolecules for Translational Approaches in Cardiology)
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Inflammation may be a risk factor for atrial fibrillation (AF). Oral infections frequently lead to chronic inflammation, such as gingivitis, periodontitis, and endodontic lesions. In this narrative review, we consider five basic pathogenic mechanisms that involve oral infections and inflammations in the pathogenesis of AF: (1) low level bacteremia by which oral bacteria enter the blood stream at inflamed sites of the oral cavity and invade the heart; (2) Systemic inflammation induced by inflammatory mediators, which are released from the sites of oral inflammation into the blood stream, affecting cardiac remodeling; (3) autoimmunity against molecular structures expressed in the heart caused by the host immune response to specific components of oral pathogens; (4) potentially arrhythmic effects mediated by activation of the autonomous nervous system triggered by oral inflammations; and (5) arrhythmic effects resulting from specific bacterial toxins that are produced by oral pathogenic bacteria. A number of studies support the involvement of all five mechanisms, suggesting a potentially complex contribution of oral inflammations to the pathogenesis of AF. View Full-Text
Keywords: oral health; atrial fibrillation; bacteremia; autoimmunity; autonomous nervous system; bacterial toxins oral health; atrial fibrillation; bacteremia; autoimmunity; autonomous nervous system; bacterial toxins

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Aarabi, G.; Schnabel, R.B.; Heydecke, G.; Seedorf, U. Potential Impact of Oral Inflammations on Cardiac Functions and Atrial Fibrillation. Biomolecules 2018, 8, 66.

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