Next Article in Journal
Acknowledgement to Reviewers of Biomolecules in 2016
Next Article in Special Issue
The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer
Previous Article in Journal
Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?
Previous Article in Special Issue
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis
Open AccessReview

DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge

1
Univ. Lille, ICPAL, EA 7365—GRITA—Groupe de Recherche sur les formes Injectables et les Technologies Associées, 3 rue du Pr. Laguesse, F-59000 Lille, France
2
FRE3600 Epigenetic Targeting of Cancer, CNRS, 31035 Toulouse, France
3
Churchill College, Cambridge CB3 0DS, UK
*
Authors to whom correspondence should be addressed.
Academic Editors: Gerda Egger and Melanie R. Hassler
Biomolecules 2017, 7(1), 3; https://doi.org/10.3390/biom7010003
Received: 15 November 2016 / Revised: 8 December 2016 / Accepted: 12 December 2016 / Published: 5 January 2017
(This article belongs to the Special Issue DNA Methylation and Cancer)
Chromatin can adopt a decondensed state linked to gene transcription (euchromatin) and a condensed state linked to transcriptional repression (heterochromatin). These states are controlled by epigenetic modulators that are active on either the DNA or the histones and are tightly associated to each other. Methylation of both DNA and histones is involved in either the activation or silencing of genes and their crosstalk. Since DNA/histone methylation patterns are altered in cancers, molecules that target these modifications are interesting therapeutic tools. We present herein a vast panel of DNA methyltransferase inhibitors classified according to their mechanism, as well as selected histone methyltransferase inhibitors sharing a common mode of action. View Full-Text
Keywords: DNA methylation; histone methylation; DNMT/HMT crosstalk; DNMT inhibitors; HMT inhibitors DNA methylation; histone methylation; DNMT/HMT crosstalk; DNMT inhibitors; HMT inhibitors
Show Figures

Figure 1

MDPI and ACS Style

Castillo-Aguilera, O.; Depreux, P.; Halby, L.; Arimondo, P.B.; Goossens, L. DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge. Biomolecules 2017, 7, 3.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop