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Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis

Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, West Bengal, India
Department of Otorhinolaryngology-Head and Neck Surgery, and the Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Authors to whom correspondence should be addressed.
Academic Editors: Gerda Egger and Melanie R. Hassler
Biomolecules 2016, 6(4), 46;
Received: 20 September 2016 / Revised: 2 November 2016 / Accepted: 7 November 2016 / Published: 24 November 2016
(This article belongs to the Special Issue DNA Methylation and Cancer)
Epigenetic modifications leading to either transcriptional repression or activation, play an indispensable role in the development of human cancers. Epidemiological study revealed that approximately 20% of all human cancers are associated with tumor viruses. Epstein-Barr virus (EBV), the first human tumor virus, demonstrates frequent epigenetic alterations on both viral and host genomes in associated cancers—both of epithelial and lymphoid origin. The cell type-dependent different EBV latent gene expression patterns appear to be determined by the cellular epigenetic machinery and similarly viral oncoproteins recruit epigenetic regulators in order to deregulate the cellular gene expression profile resulting in several human cancers. This review elucidates the epigenetic consequences of EBV–host interactions during development of multiple EBV-induced B-cell lymphomas, which may lead to the discovery of novel therapeutic interventions against EBV-associated B-cell lymphomas by alteration of reversible patho-epigenetic markings. View Full-Text
Keywords: Epstein-Barr virus; B-cell lymphoma; Epigenetics Epstein-Barr virus; B-cell lymphoma; Epigenetics
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Ghosh Roy, S.; Robertson, E.S.; Saha, A. Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis. Biomolecules 2016, 6, 46.

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