Structural Biology of Bacterial RNA Polymerase
AbstractSince its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterial RNAP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription. View Full-Text
Share & Cite This Article
Murakami, K.S. Structural Biology of Bacterial RNA Polymerase. Biomolecules 2015, 5, 848-864.
Murakami KS. Structural Biology of Bacterial RNA Polymerase. Biomolecules. 2015; 5(2):848-864.Chicago/Turabian Style
Murakami, Katsuhiko S. 2015. "Structural Biology of Bacterial RNA Polymerase." Biomolecules 5, no. 2: 848-864.