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Structural Biology of Bacterial RNA Polymerase

Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
Academic Editors: Sivaramesh Wigneshweraraj and Deborah M. Hinton
Biomolecules 2015, 5(2), 848-864; https://doi.org/10.3390/biom5020848
Received: 9 March 2015 / Revised: 10 April 2015 / Accepted: 13 April 2015 / Published: 11 May 2015
(This article belongs to the Special Issue Bacterial RNA Polymerase)
Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterial RNAP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription. View Full-Text
Keywords: bacterial RNA polymerase; transcription; core enzyme; holoenzyme; σ factor; transcription factor; anti-σ factor; X-ray crystallography; NMR; inhibitor antibiotic bacterial RNA polymerase; transcription; core enzyme; holoenzyme; σ factor; transcription factor; anti-σ factor; X-ray crystallography; NMR; inhibitor antibiotic
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Murakami, K.S. Structural Biology of Bacterial RNA Polymerase. Biomolecules 2015, 5, 848-864.

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